{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:10:32Z","timestamp":1781129432274,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the prevalence of electrolyte and kidney function alterations in infants \u2264\u200990\u2009days with febrile urinary tract infection (UTI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Secondary analysis of a prospective registry including infants \u2264\u200990\u2009days with fever without a source seen between 2010 and 2022 in an emergency department. We analysed electrolyte and kidney function laboratory parameters in relation to the definitive diagnosis and a group of healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We registered 2361 episodes: 495 UTI (34 with an associated invasive bacterial infection [IBI]), 43 IBI not related to a UTI, and 1823 without bacterial infection. Further, we included 205 healthy controls. The median duration of fever was 4\u2009h, and 98.5% were well appearing.<\/jats:p>\n                    <jats:p>Among infants with UTI without an associated IBI, blood creatinine levels were abnormal in 0.2%, urea in 1.1% and glomerular filtration rate in 3.2%, similar to infants not diagnosed with bacterial infections and healthy controls, and significantly lower than in those with UTI and an associated IBI (9.4%, 18.1% and 17.2% respectively). No patients had signs or symptoms of acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Electrolyte imbalance and kidney function impairment are rare in well\u2010appearing infants younger than 90\u2009days with febrile UTI and a short duration of fever.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70291","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:06:08Z","timestamp":1756469168000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electrolyte Imbalance in Infants Younger Than 90\u2009Days of Age With Febrile Urinary Tract Infection"],"prefix":"10.1111","volume":"115","author":[{"given":"M.","family":"Serrano Oarbeaskoa","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Camarero Pagonabarraga","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Iriarte Uribeecheverria","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-2423","authenticated-orcid":false,"given":"I.","family":"Gangoiti","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-4494","authenticated-orcid":false,"given":"B.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jimenez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hospital Universitario Cruces  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-8881","authenticated-orcid":false,"given":"S.","family":"Mintegi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces, Universidad del Pa\u00eds Vasco  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000000482"},{"key":"e_1_2_10_3_1","first-page":"4","volume-title":"UpToDate","author":"Shaikh N.","year":"2015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2019.01.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002461"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.00000000000003947"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/APA.16881"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20104381"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3181d6db37"},{"issue":"6","key":"e_1_2_10_10_1","first-page":"400.e1","article-title":"Recommendations on the Diagnosis and Treatment of Urinary Tract Infection","volume":"90","author":"P\u00e9rez R. P.","year":"2019","journal-title":"Anales de Pediatr\u00eda (Barcelona, Spain)"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/APA.12789"},{"key":"e_1_2_10_12_1","first-page":"642","volume-title":"The Harriet Lane Handbook","author":"Tschudy K. M.","year":"2012"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"326.e1","article-title":"Consensus Document: Recommendations on the Use of Equations for the Estimation of Glomerular Filtration Rate in Children","volume":"80","author":"Monta\u00f1\u00e9s R.","year":"2014","journal-title":"Anales de Pediatr\u00eda (Barcelona, Spain)"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00431\u2010023\u201005149\u2010Z"},{"key":"e_1_2_10_15_1","unstructured":"Asociaci\u00f3n Espa\u00f1ola de Nefrolog\u00eda Pedi\u00e1trica \u201cAENP Guideline: Clinical Practice Guidelines on Urinary Tract Infection in the Paediatric Population \u201d(2024) https:\/\/www.aenp.es\/actividades\/guias\u2010de\u2010practica\u2010clinica.html."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxad085"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021\u2010055633"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAPEDIATRICS.2018.5501"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39244.692442.55"},{"key":"e_1_2_10_20_1","volume-title":"UpToDate","author":"Warady B. 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