{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:58:45Z","timestamp":1792616325217,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria\u2010Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We discuss the benefits and potential side effects of vaccines for tetanus\u2010diphtheria\u2010acellular pertussis, influenza, COVID\u201019, respiratory syncytial virus and monkeypox. The future use of cytomegalovirus and group B streptococcus vaccines is also covered. Vaccine hesitancy, mainly due to fears of harming the foetus, including preterm delivery, is addressed. The use of evidence\u2010based information to allay fears is explored. Ethical issues about the potential side effects of vaccinating mothers, primarily for the good of the infant, are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The vaccines we looked at were generally effective and safe, with no considerable adverse effects for the mother\u2013infant dyad. Vaccination hesitancy was predominately based on fears about the adverse effects on the foetus. These can mainly be combated by health professionals providing clear information on the impact on both the mother and her offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The vaccines discussed in the paper were generally effective and safe for the mother, foetus and infant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70301","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T07:39:52Z","timestamp":1758958792000},"page":"2380-2388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vaccinations During Pregnancy Protect the Mother\u2013Infant Dyad and Are Generally Safe"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-1573","authenticated-orcid":false,"given":"Ariadne","family":"Malamitsi\u2010Puchner","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Third Department of Paediatrics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-6036","authenticated-orcid":false,"given":"Despina D.","family":"Briana","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Third Department of Paediatrics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-240X","authenticated-orcid":false,"given":"Gian Carlo","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"PREIS School, International and European School of Perinatal, Neonatal and Reproductive Medicine  Florence Italy"},{"name":"Department of Obstetrics, Gynecology and Perinatology I.M. Sechenov First State University of Moscow  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1455318"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13456"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001440"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.136"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.07.053"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10121990"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.689394"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.04.043"},{"key":"e_1_2_13_10_1","unstructured":"\u201cTetanus Vaccine Recommendations \u201dhttps:\/\/www.cdc.gov\/tetanus\/vaccines\/recommendations.html."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.12.019"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29669"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1345385"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2450858"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126671"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40965-9"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.14028"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.39792"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01666-2"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.01.006"},{"key":"e_1_2_13_21_1","unstructured":"\u201cCDC \u2013 Pregnancy and Recently Pregnant People \u201d2021."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004633"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000538135"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36547-4"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.02.008"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062600"},{"key":"e_1_2_13_27_1","unstructured":"WHO \u201cRespiratory Syncytial Virus (RSV) \u201d2025."},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_13_29_1","unstructured":"\u201cWorld Health Organization and PATH \u201d2024."},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00811-5"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy167"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2106062"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216480"},{"key":"e_1_2_13_34_1","unstructured":"\u201cRSV Vaccine Guidance for Pregnant Women \u201dhttps:\/\/www.cdc.gov\/rsv\/hcp\/vaccine\u2010clinical\u2010guidance\/pregnant\u2010people.html."},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7241e1"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005816"},{"key":"e_1_2_13_37_1","unstructured":"\u201cWHO Position Paper on Immunization to Protect Infants Against Respiratory Syncytial Virus Disease May 2025 \u201dhttps:\/\/www.who.int\/publications\/i\/item\/who\u2010wer\u201010022\u2010193\u2010218."},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(25)00156\u20102"},{"key":"e_1_2_13_39_1","unstructured":"T. C.Williams R.Marlow S.Cunningham et\u00a0al. \u201cBivalent Prefusion F Vaccination in Pregnancy and Respiratory Syncytial Virus Hospitalisation in Infants: Results of a Prospective Multi\u2010Centre Test\u2010Negative Study \u201dSocial Science Research Network https:\/\/ssrn.com\/abstract=5184994."},{"key":"e_1_2_13_40_1","unstructured":"M.DeSilva \u201cRSVpreF Vaccine Preterm Birth and Small for Gestational Age at Birth Preliminary Results From the Vaccine Safety Datalink \u201dPresented to the Advisory Committee on Immunization Practices October 2024 https:\/\/www.cdc.gov\/acip\/downloads\/slides\u20102024\u201010\u201023\u201024\/03\u2010RSV\u2010Mat\u2010Peds\u2010DeSilva\u2010508.pdf."},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.19268"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2210828"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00607-1"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17040456"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2410045"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.06.020"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac482"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06367-5"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31868-7"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae114"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.11.056"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123014"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.07.051"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00093-6"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116045"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.056"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.10.041"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13245"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.04.024"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz360"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.05.062"},{"key":"e_1_2_13_62_1","unstructured":"\u201cTen Threats to Global Health in 2019 \u201dhttps:\/\/www.who.int\/news\u2010room\/spotlight\/ten\u2010threats\u2010to\u2010global\u2010health\u2010in\u20102019."},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2024.117526"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2458353"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2024.0950"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.231522"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.2196\/54769"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2450131"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.126767"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2024.2411823"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2481003"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126568"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126495"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30349-8"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:33:47Z","timestamp":1792614827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,27]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/apa.70301"],"URL":"https:\/\/doi.org\/10.1111\/apa.70301","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,27]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}