{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:19:16Z","timestamp":1776723556387,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Solitary functioning kidney (SFK) is linked to chronic kidney disease (CKD) in children, particularly when associated with congenital anomalies of the kidney and urinary tract (CAKUT). Pelvi\u2010ureteric junction obstruction (PUJO) is the most frequent obstructive uropathy in SFK. This study aimed to evaluate long\u2010term kidney function in children operated on for PUJO in an SFK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Among a retrospective cohort study of children with an SFK, a subgroup analysis was performed: primary SFK with operated PUJO (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935); primary SFK without CAKUT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009108); primary SFK with CAKUT other than PUJO (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). Markers of CKD and measured glomerular filtration rate were assessed during follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Surgery was indicated because of neonatal acute kidney injury (AKI) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), worsening renal pelvis dilation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910). The median age at surgery was 15 months (1.2\u201330\u2009months). At a median age of 13\u2009years at last follow\u2010up, the proportion of CKD was higher in primary SFK with PUJO compared to primary SFK without CAKUT (43% vs. 12%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008). In SFK\/PUJO, neonatal AKI was predictive of subsequent CKD (OR 4.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PUJO in an SFK is associated with a high rate of CKD during childhood, particularly when neonatal AKI is present.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70303","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:03:06Z","timestamp":1758621786000},"page":"196-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pelvi\u2010Ureteric Junction Obstruction in a Solitary Functioning Kidney in Children: An Unfavourable Combination"],"prefix":"10.1111","volume":"115","author":[{"given":"Mathilde","family":"Grapin","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology, H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA) H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Rabaux","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, H\u00f4pital Necker\u2010Enfants Malades Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Glenisson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, H\u00f4pital Necker\u2010Enfants Malades Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Mille","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, H\u00f4pital Necker\u2010Enfants Malades Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Biebuyck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA) H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Preka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA) H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA) H\u00f4pital Necker\u2010Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-9966","authenticated-orcid":false,"given":"Kiarash","family":"Taghavi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, H\u00f4pital 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