{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:20:55Z","timestamp":1790706055967,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021732","name":"Aotearoa Foundation","doi-asserted-by":"publisher","award":["9909494"],"award-info":[{"award-number":["9909494"]}],"id":[{"id":"10.13039\/501100021732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/690"],"award-info":[{"award-number":["19\/690"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Neonatal hypoglycaemia is a common metabolic disorder in newborns; if severe or prolonged, it can lead to brain injury. Formula is sometimes used to treat neonatal hypoglycaemia. This study aims to synthesise evidence on the effectiveness of infant formula for the prevention and treatment of neonatal hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomised controlled trials (RCTs) and cohort studies comparing infants given formula to those who were not were included. Four databases and four trial registries were searched. Study quality was evaluated using the Cochrane Risk of Bias\u20101 tool for RCTs and the Newcastle\u2010Ottawa Scale for cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We screened titles and abstracts of 6711 records and full texts of 56 records. We included 12 studies: one RCT and 11 cohort studies. For prevention, the evidence is very uncertain about the effect of formula on neonatal hypoglycaemia (621 infants, OR 3.01 [0.53 to 17.13],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.21,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200985%, very low certainty evidence). One RCT showed that formula may be more likely to correct neonatal hypoglycaemia than oral dextrose gel (222 infants, RR 1.27 [1.11 to 1.46],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004, low certainty evidence).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The effect of formula in preventing neonatal hypoglycaemia remains uncertain; although formula may be more effective than oral dextrose gel in correcting hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      This review was registered in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=581348\">PROSPERO (CRD42024581348)<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70325","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:25:22Z","timestamp":1760167522000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Infant Formula for the Prevention and Treatment of Neonatal Hypoglycaemia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0422-9601","authenticated-orcid":false,"given":"Ariba","family":"Iqbal","sequence":"first","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-1422","authenticated-orcid":false,"given":"Jane E.","family":"Harding","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-1504","authenticated-orcid":false,"given":"Luling","family":"Lin","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.044"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.12.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.09.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.562251"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2016.08.007"},{"key":"e_1_2_11_8_1","volume-title":"Identification and Management of Neonatal Hypoglycaemia in the Full Term Infant (birth \u2013 72 Hours) \u2010 Framework for Practice","author":"British Association of Perinatal Medicine","year":"2024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14955"},{"key":"e_1_2_11_10_1","volume-title":"Hypoglycaemia of the Newborn: Christchurch Women's Hospital 2020","author":"Maternity Guidelines Group","year":"2020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2009.01599.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2023-000544"},{"key":"e_1_2_11_13_1","volume-title":"Hypoglycaemia\u2013Newborn","author":"Queensland Clinical Guidelines","year":"2023"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.srhc.2018.10.003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0093"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19840074"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_18_1","volume-title":"Covidence Systematic Review Software Melbourne, Australia","author":"Veritas Health Innovation","year":"2024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_11_20_1","unstructured":"G.Wells B.Shea D.O'Connell et\u00a0al. \u201cThe Ottawa Hospital \u201d(2021) https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_11_21_1","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann H.","year":"2013"},{"key":"e_1_2_11_22_1","volume-title":"GRADEpro GDT: GRADEpro Guideline Development Tool","year":"2024"},{"key":"e_1_2_11_23_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 65","author":"Sch\u00fcnemann H. 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