{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T10:14:10Z","timestamp":1771150450579,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To diagnose newborn infants with congenital cytomegalovirus (cCMV) related sensorineural hearing loss (SNHL) within the critical four\u2010week window for initiating antiviral treatment, we aimed to determine the number needed to test (NNT) for cCMV among newborn infants failing the neonatal hearing screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A population\u2010based multicenter cohort study included newborn infants in East Denmark who failed two hearing screening tests and underwent saliva CMV screening between November 2021 and May 2024. The NNT was calculated as the inverse of the absolute detection rate of cCMV\u2010related SNHL in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 484 infants with hearing screening failure were tested for cCMV. Of these, 27 (5.6%) were CMV positive in saliva and 7 (1.5%) were confirmed to have cCMV in urine, blood, or dried blood spots. Six (85.7%) of 7 infants with cCMV and initial hearing screening failure had normal hearing at follow\u2010up, leaving 1 (0.2%) of 484 with cCMV\u2010related SNHL and an NNT of 484 (95% CI 87\u201020\u2009000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our setting, targeted screening for cCMV resulted in a high NNT of almost 500 to identify one newborn infant with cCMV\u2010related SNHL, reflecting a low incidence of cCMV\u2010related SNHL and a high risk of false\u2010positive hearing screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70326","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:39:24Z","timestamp":1760503164000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Screening for Congenital Cytomegalovirus in the Newborn Hearing Screening Program: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"115","author":[{"given":"Luana Uchoa","family":"Karvig","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3684-2963","authenticated-orcid":false,"given":"Emilie Luppescu","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Slagelse Hospital  Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Herlev Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbeth Sams\u00f8","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Herlev Hospital  Herlev Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-1858","authenticated-orcid":false,"given":"L\u00e6rke Vinge","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bille","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery and Audiology, Copenhagen Hearing and Balance Center, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma Malchau","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Hvidovre Hospital  Hvidovre 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