{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T10:13:57Z","timestamp":1771150437907,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Congenital cytomegalovirus is the leading cause of non\u2010genetic hearing loss in children. This study aimed to evaluate if hearing\u2010targeted screening for congenital cytomegalovirus was implementable and whether it improved timely treatment of affected newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included newborns who did not pass hearing screening in Region Zealand, Denmark. The study period was 1 June 2018 to 31 May 2024, covering 4\u2009years before and 2\u2009years after the implementation of hearing\u2010targeted cytomegalovirus screening. We compared the proportion of infants tested, age at testing, and the use of saliva and urine samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the 6\u2009years, 615 infants did not pass the hearing screening. Before the implementation of hearing targeted screening, 21 of 349 referred infants (6%) were tested for cytomegalovirus. By the second year of implementation, testing increased to 113 (90%). Saliva and urine samples were collected from the same number of infants. Nine of 11 positive saliva samples were not confirmed infections. No children with cytomegalovirus\u2010related hearing loss were diagnosed in time to initiate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our setting, hearing targeted cytomegalovirus screening was gradually implemented, but had low diagnostic yield. Urine samples seemed preferable to saliva for targeted screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70354","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:19:25Z","timestamp":1761070765000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Cytomegalovirus Testing Linked to Newborn Hearing Screening Was Feasible but Had Low Diagnostic Yield"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3684-2963","authenticated-orcid":false,"given":"Emilie Luppescu","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Slagelse Hospital  Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten Fenger","family":"Hvilsted","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Slagelse Hospital  Slagelse Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Holbaek Hospital  Holbaek Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janko","family":"Moritz","sequence":"additional","affiliation":[{"name":"Department of Audiology Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Heilmann","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristo","family":"Stanchev","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina Vasehus","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Region Zealand  Slaglelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke Lykke","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Region Zealand  Slaglelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui Chen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Region Zealand  Slaglelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Zaharova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Nyk\u00f8bing Falster Hospital  Nykoebing Falster Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe Vestergaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Holbaek Hospital  Holbaek Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrikka","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-211X","authenticated-orcid":false,"given":"Stine","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital of Northern Zealand  Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren Johanne Heilskov","family":"Rytter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Slagelse Hospital  Slagelse Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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