{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T10:14:26Z","timestamp":1771150466584,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. Clinical and metabolic parameters and neurological assessments were recorded before the initiation of TH using a standardised electronic form in REDCap, a secure web\u2010based platform for clinical research. Correlations between metabolic indicators (pH, base deficit, lactate) and neurological assessments, including Sarnat score, Thompson score and initial amplitude\u2010integrated electroencephalography (aEEG) were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean gestational age was 39.4\u2009\u00b1\u20091.7\u2009weeks. Acidosis and abnormal aEEG patterns were the most frequent criteria initiating treatment. Lower pH was strongly associated with abnormal aEEG (odds ratio 0.02, 95% confidence interval 0.002\u20130.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Base deficit and lactate showed weaker, non\u2010significant associations. Lower 10\u2010min Apgar scores predicted abnormal aEEG (odds ratio 0.77, 95% confidence interval 0.69\u20130.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe acidosis (pH &lt;\u20097.0) was significantly associated with abnormal aEEG patterns, the main determinant initiating TH. Identifying abnormal aEEG patterns is essential for confirming moderate to severe encephalopathy and guiding treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70360","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:29:57Z","timestamp":1761798597000},"page":"482-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abnormal Amplitude\u2010Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns\u00a0\u2010 Data From the German Hypothermia Registry"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4614-9377","authenticated-orcid":false,"given":"Sebiha","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Children's Hospital University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Groteklaes","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Children's Hospital University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Dresbach","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Children's Hospital University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-5430","authenticated-orcid":false,"given":"Andreas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Children's Hospital University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemmen","family":"Sabir","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Children's Hospital University of Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the German Hypothermia Registry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2024.110309"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247229"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-17"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0200-y"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03184-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxy028"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11060686"},{"key":"e_1_2_14_10_1","unstructured":"Yorkshire and Humber ODN Pan Network \u201cManagement of Hypoxic Ischaemic Encephalopathy Including Therapeutic Hypothermia \u201d Adapted From the NTNN and YNN Guidelines (2021)."},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005392"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-326102"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315711"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1004086"},{"key":"e_1_2_14_15_1","unstructured":"Perinatalzentren.org \u201cList of Perinatal Centers in Germany \u201d Perinatalzentren."},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14979"},{"key":"e_1_2_14_17_1","unstructured":"J.Proietti G. 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H.Walsh \u201cRegional Variability in Therapeutic Hypothermia Eligibility Criteria for Neonatal Hypoxic\u2010Ischemic Encephalopathy \u201d accessed February 6 2025 https:\/\/www.nature.com\/articles\/s41390\u2010024\u201003184\u20106."},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2016.05.009"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1624\/105812400X87716"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8050380"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08581.x"},{"key":"e_1_2_14_23_1","article-title":"Amplitude\u2010Integrated EEG in Infants at Risk of Hypoxic\u2010Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia","volume":"208","author":"Wilson A.","year":"2024","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.114407"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13810"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.114411"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.06.005"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.11.004"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00175-1"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k207"},{"issue":"2","key":"e_1_2_14_31_1","article-title":"Pathophysiology of Perinatal Asphyxia in Humans and Animal Models","volume":"10","author":"Mota\u2010Rojas D.","year":"2022","journal-title":"Biomedicine"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:59:21Z","timestamp":1771149561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/apa.70360"],"URL":"https:\/\/doi.org\/10.1111\/apa.70360","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}