{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T17:07:19Z","timestamp":1771175239206,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["00057349"],"award-info":[{"award-number":["00057349"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","award":["2023\u20108370"],"award-info":[{"award-number":["2023\u20108370"]}],"id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019562","name":"Synoptik-Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the prevalence, severity and diagnostic value of reduced visual acuity (VA) in children with primary brain tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All children (&lt;\u200918\u2009years) diagnosed with a primary brain tumour in Denmark during 2007\u20132017 were included in this nationwide retrospective study. The children were identified through the Danish Childhood Cancer Registry. Patient records from hospitals and private ophthalmologists were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Reduced VA was observed in 18.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200987\/464) of children with primary brain tumours and was the initial tumour sign in 12.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911\/87) of these cases. The median total diagnostic interval (TDI) for children whose initial tumour manifestation was reduced VA was 206\u2009days (range: 46\u2013718), whereas for those whose initial tumour sign was any other sign, the TDI was 86\u2009days (range: 0\u20133000). Among children with reduced VA, 39.4% of those aged \u2264\u20096\u2009years and 20.4% of those aged &gt;\u20096\u2009years had monocular vision impairment in their best\u2010seeing eye. Optic disc abnormality (59.8%) was the most common accompanying ophthalmic tumour sign.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced VA was frequent in children with brain tumours and typically occurred alongside other tumour signs. Timely diagnosis relies on close collaboration between paediatricians and ophthalmologists to identify additional tumour signs and determine the need for prompt neuroimaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70361","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:10:41Z","timestamp":1763370641000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Vision in Children With Brain Tumours in Denmark\u2014Prevalence, Severity, and Diagnostic Importance"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-5059","authenticated-orcid":false,"given":"C. S. K.","family":"Schmidt","sequence":"first","affiliation":[{"name":"The Laboratory of Pediatric Oncology, Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Ophthalmology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mathiasen","sequence":"additional","affiliation":[{"name":"The Laboratory of Pediatric Oncology, Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-9844","authenticated-orcid":false,"given":"K. S.","family":"Weile","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Pathology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-6931","authenticated-orcid":false,"given":"S. L.","family":"von Holstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4429"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(18)30095\u20106"},{"key":"e_1_2_13_4_1","volume-title":"Guide to Cancer Early Diagnosis","author":"World Health Organization","year":"2017"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(07)70207\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2018.09.016"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31128"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov187"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99508"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12366"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191\u20103913\u201019940901\u201010"},{"issue":"3","key":"e_1_2_13_12_1","first-page":"657","article-title":"Large Sample Population Age Norms for Visual Acuities Obtained With Vistech\u2010Teller Acuity Cards","volume":"36","author":"Salom\u00e3o S. 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