{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T17:07:11Z","timestamp":1771175231183,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study forecasts the global burden of ultrasound\u2010diagnosed MASLD in adolescents (15\u201319\u2009years) from 2020 to 2030, examining socioeconomic influences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using generalised additive models (GAM) and estimated annual percentage change (EAPC), age\u2010standardised incidence (ASIR), mortality (ASDR) and disability\u2010adjusted life years (DALYs) rates were projected. Regional analyses used the Socio\u2010Demographic Index (SDI), with regression models quantifying associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global ASIR is projected to rise significantly (EAPC: +1.46%), outpacing slower increases in DALYs (EAPC: +0.20%) and ASDR (EAPC: +0.18%). High\u2010income North America faces the steepest ASIR surge (EAPC: +2.52%), while Central\/Eastern Europe and Central Asia are stable. By 2030, low\u2010SDI regions will have the highest median ASIR, with Turkmenistan predicted to have the world's highest (0.77 per 100\u2009000). Striking disparities exist: higher SDI strongly correlates with elevated ASIR in Europe (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.339), indicating lifestyle risks in affluent settings. Conversely, higher SDI correlates with reduced DALYs\/ASDR elsewhere. Despite some declines in low\u2010SDI areas, high\u2010income North America and vulnerable low\u2010SDI regions (e.g., Turkmenistan) face escalating burdens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Socioeconomic factors and lifestyle disparities drive divergent global adolescent MASLD trajectories. Without intervention, the burden will surge by 2030\u2014particularly in high\u2010income North America and low\u2010SDI hotspots\u2014demanding region\u2010specific policies to address metabolic health inequities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70373","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:37:57Z","timestamp":1763714277000},"page":"651-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alarming Global Rise in Adolescent Metabolic Dysfunction\u2010Associated Steatotic Liver Disease by 2030"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9352-7259","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Ningbo No.2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Ningbo No.2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"7","key":"e_1_2_13_2_1","first-page":"797","article-title":"Progress in the Management of NAFLD\/NASH","volume":"64","author":"Aizawa Y.","year":"2016","journal-title":"Rinsho Byori"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15852"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.022"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29068"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(24)00530-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1721169"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17292"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i19.2083"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2023.01.002"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.08.011"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31889"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32228"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1047129"},{"key":"e_1_2_13_17_1","first-page":"121","article-title":"Trend of Gastrointestinal and Liver Diseases in Iran: Results of the Global Burden of Disease Study, 2010","volume":"7","author":"Sepanlou S. 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