{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T17:07:20Z","timestamp":1771175240821,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Screening criteria for retinopathy of prematurity (ROP) vary among countries. Early detection of ROP and minimising the burden of screening are important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from very preterm infants born in Switzerland between 2006 and 2022. Logistic regression models were fitted to evaluate 17 potential risk factors for ROP treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      168\/11354 patients (median (range) gestational age (GA) 29.6 (23.0\u201331.9) weeks) required ROP treatment. All would have been detected and screening burden would have been reduced by 56% if screening had required meeting \u2265\u20091 of the following criteria: GA &lt;\u200927\u2009weeks (89.3%), birth weight\u2009&lt;\u20091000\u2009g (97.0%), intraventricular haemorrhage\u2265II\u00b0 (24.0%), congenital tumour (1.2%). We identified six statistically significant risk factors for ROP: GA (adjusted odds ratio (aOR) 0.46, 95% CI 0.40\u20130.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), birth weight z\u2010score (aOR 0.58, 95% CI 0.46\u20130.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), duration of supplemental oxygen (aOR 1.01 95% CI 1.01\u20131.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), duration of mechanical ventilation (OR 1.01, 95% CI 1.00\u20131.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), caesarean section (OR 1.84, 95% CI 1.06\u20133.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), and congenital tumour (OR 26.3, 95% CI 2.71\u2013189,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The model allowed for excellent prediction of ROP treatment (AUC 0.963, 95% CI 0.944\u20130.981).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Safely reducing the burden of ROP screening appears achievable in Switzerland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70381","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:19:58Z","timestamp":1764087598000},"page":"671-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population\u2010Based Cohort Study for Development of National Retinopathy of Prematurity Screening Criteria"],"prefix":"10.1111","volume":"115","author":[{"given":"R.","family":"Gerull","sequence":"first","affiliation":[{"name":"Department of Neonatology University Children's Hospital Basel UKBB  Basel Switzerland"},{"name":"Faculty of Medicine University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Pediatric Research Centre, University Children's Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-8315","authenticated-orcid":false,"given":"A.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Pediatric Research Centre, University Children's Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Division of Infectious Diseases &amp; Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schuler\u2010Barazzoni","sequence":"additional","affiliation":[{"name":"Clinic of Neonatology, Department Woman\u2010Mother\u2010Child, University Hospital of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Newborn Research University Hospital Zurich (USZ), University of Zurich (UZH)  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7143-6117","authenticated-orcid":false,"given":"F.","family":"Barcos Munoz","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit University Hospital of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gerth\u2010Kahlert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich and University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Schulzke","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Children's Hospital Basel UKBB  Basel Switzerland"},{"name":"Faculty of Medicine University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Swiss Neonatal Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-093022-021420"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15468"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310532"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.05.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-310041"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.5.425"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-024-02107-x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0744-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053924"},{"key":"e_1_2_12_12_1","unstructured":"https:\/\/app.swissneonet.ch\/data\/live\/structure\/mnds."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_12_16_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"issue":"3","key":"e_1_2_12_17_1","first-page":"346","article-title":"Retinopathy of Prematurity\u2014Update on Classification, Screening, and Therapy","volume":"239","author":"Li J. Q.","year":"2022","journal-title":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3061"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313574"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15197"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2024.151928"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03245-w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0128-3"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"issue":"2","key":"e_1_2_12_25_1","first-page":"6","article-title":"The Role of Oxygen in Retrolental Fibroplasia","volume":"3","author":"Patz A.","year":"1954","journal-title":"Sinai Hospital Journal (Baltimore)"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.38.7.397"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.12.155"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-1966-y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521413"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0803"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.69"},{"key":"e_1_2_12_32_1","first-page":"667","article-title":"Systematic Review of the Guidelines for Retinopathy of Prematurity","author":"Kosciolek M.","year":"2022","journal-title":"European Journal of Ophthalmology"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517247"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-319929"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T16:43:04Z","timestamp":1771173784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/apa.70381"],"URL":"https:\/\/doi.org\/10.1111\/apa.70381","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}