{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:13:18Z","timestamp":1778083998799,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Children with acute lymphoblastic leukaemia (ALL) are at risk of metabolic and cardiovascular complications. We evaluated the development of overweight and obesity for 5\u2009years after diagnosis in children and adolescents treated for ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of children diagnosed with ALL at one centre during 2000\u20132018 were assessed. Weight and height measurements were retrieved from medical records and were used to calculate age\u2010 and sex\u2010adjusted International Obesity Task Force\u2010Body Mass Index (ISO\u2010BMI). ISO\u2010BMI was determined at selected time points during treatment and up to 5\u2009years after diagnosis, and the change in mean ISO\u2010BMI was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 115 patients diagnosed with ALL, 54 (47%) of whom were male. Mean age at diagnosis was 6.6\u2009\u00b1\u20094.6 (range 0\u201317.99) years. ISO\u2010BMI increased significantly during treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and remained elevated at 5\u2009years after diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The number of overweight and obese patients increased from 17% and 4% at diagnosis to 26% and 16% at the five\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients treated for ALL are at significant risk of weight gain and obesity, with the prevalence of overweight and obesity doubling from diagnosis to 5\u2009years post\u2010treatment. ISO\u2010BMI remained persistently elevated across all treatment risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70413","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:24:37Z","timestamp":1765599877000},"page":"858-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010 and Sex\u2010Adjusted Body Mass Index Increases in Childhood Acute Lymphoblastic Leukaemia Patients From Diagnosis to Five\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"115","author":[{"given":"Aino","family":"Kyt\u00f6m\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Huurre","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi M.","family":"L\u00e4hteenm\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku  Turku Finland"},{"name":"Department of Women's and Children's Health, Registry Group Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-3635","authenticated-orcid":false,"given":"Liisa S.","family":"J\u00e4rvel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku  Turku 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