{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:13:11Z","timestamp":1778083991056,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Prenatal maternal infections may impair infant brain development. This study investigated the effect of maternal infections with the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) during pregnancy on infant neurodevelopment by assessing general movements (GMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Infants were recruited for this multicenter prospective cohort study from LMU University Hospital sites in Munich after birth or during routine visits. GMs were recorded and assessed between 1 July 2022 and 31 January 2023, using the Hadders\u2010Algra method. Odds ratios for abnormal GMs were calculated for infants with parent\u2010reported prenatal SARS\u2010CoV\u20102 exposure compared to unexposed controls. Specific GM subgroups were analysed at preterm, writhing, and fidgety ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study comprised 114 exposed infants (55.3% male) and 92 controls (54.3% male). There were no significant differences between the groups at birth. Two of the mothers were infected twice and one of them required hospitalisation. GMs were assessed at a mean corrected age (CA) of 4\u2009weeks. The odds ratios showed no significant differences in GM quality between exposed infants and controls in either the total group or the subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prenatal exposure to SARS\u2010CoV\u20102 did not affect early neurodevelopment, which was determined by GM quality. Further studies should include long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The study was registered at the German Clinical Trial Register (ID: DRKS00029247;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/de\/trial\/DRKS00029247\">https:\/\/drks.de\/search\/de\/trial\/DRKS00029247<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70420","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:22:21Z","timestamp":1766388141000},"page":"913-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infants' General Movements Were Not Affected by Exposure to Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infections"],"prefix":"10.1111","volume":"115","author":[{"given":"Kathrin","family":"Neumayr","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology and Developmental Medicine, iSPZ Hauner MUC, Dr. von Hauner Children's Hospital, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Lippert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology and Developmental Medicine, iSPZ Hauner MUC, Dr. von Hauner Children's Hospital, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Sebastian","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Center for Child Neurology and Social Pediatrics Child Center Maulbronn  Maulbronn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinzenz G.","family":"Eck","sequence":"additional","affiliation":[{"name":"Expert Analytics GmbH R&amp;D for Digital Innovations  Gauting Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Tacke","sequence":"additional","affiliation":[{"name":"University Children's Hospital Basel Pediatric Neurology  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-8610","authenticated-orcid":false,"given":"Sevil","family":"\u00dczer","sequence":"additional","affiliation":[{"name":"Center for Child Neurology and Social Pediatrics Child Center Maulbronn  Maulbronn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas W.","family":"Flemmer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Klemme","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-6717","authenticated-orcid":false,"given":"Claudia","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Dr. von Hauner Children's Hospital, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"Hesse","sequence":"additional","affiliation":[{"name":"Swiss Children's Rehab and Children's Research Center, University Children's Hospital Zurich  Affoltern am Albis Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Pujades","sequence":"additional","affiliation":[{"name":"Inria, Univ. 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