{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:15:43Z","timestamp":1778084143541,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated whether family composition and other household factors are associated with adherence to vitamin D supplementation during infancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional survey was conducted between March 21 and April 30, 2023, among caregivers of infants aged 4\u2009weeks to 12\u2009months at the Ca\u2032 Granda Hospital, Milan, Italy. The survey investigated demographic data, health status, daily vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      administration frequency, and family characteristics. Multiple logistic regression was used to identify factors associated with poor adherence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 241 caregivers completed the survey. Overall, 85% of infants received vitamin D supplements at least four times per week. Good adherence was more frequent in families with one child (91%) compared with those with two or more children (78%). In multivariable analysis, the presence of siblings was the only factor significantly associated with poor adherence (odds ratio 2.72, 95% confidence interval 1.25\u20135.92). No associations were found with caregiver education, infant age, chronic disease, intercurrent illness, or time spent outdoors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort, adherence to vitamin D prophylaxis was significantly lower in families with more than one child. Awareness of this association could inform counselling strategies and the design of interventions to sustain adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70435","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:24:08Z","timestamp":1767201848000},"page":"959-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lower Adherence to Vitamin D Prophylaxis in Families With Multiple Children"],"prefix":"10.1111","volume":"115","author":[{"given":"Martina","family":"Panicola","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Cereghetti","sequence":"additional","affiliation":[{"name":"Family Medicine, Faculty of Biomedical Sciences Universit\u00e0 Della Svizzera Italiana  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-0832","authenticated-orcid":false,"given":"Carlo","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 Degli Studi di Milano  Milan Italy"},{"name":"Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Alberti","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-5908","authenticated-orcid":false,"given":"Emilia","family":"Vassilopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 Degli Studi di Milano  Milan 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