{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:53:49Z","timestamp":1791417229302,"version":"4.3.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n The incidence of neonatal abstinence syndrome (NAS) has risen, but published data are limited. The aim of this study was to investigate the incidence of NAS and the associated prenatal drug exposure in a Danish population.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a historical multicentre cohort study of neonates treated for NAS during 2013\u20132018. The Danish National Patient Register identified 447 neonates with one of four predefined diagnoses. Reviews of the medical records showed that 98 of the neonates were pharmacologically treated for NAS.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The incidence of NAS in the 6\u2010year period was stable at 0.6 per 1000 live births. The majority of neonates treated for NAS were born to mothers treated with analgesic opioids. However, one\u2010third of the neonates treated for NAS were not exposed to opioids. The most frequent other drugs causing NAS were cannabis, benzodiazepines, antidepressants and psychoactive drugs. Half of the neonates were only exposed to a single drug; 14% were exposed to cannabis and 9% of all neonates treated for NAS were exposed to cannabis as a single drug in addition to tobacco.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The incidence of NAS in the 6\u2010year period was stable. Healthcare professionals should be aware of NAS after prenatal exposure to cannabis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apa.70443","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:34:47Z","timestamp":1767807287000},"page":"1043-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Incidence of Neonatal Abstinence Syndrome Remained Stable in Eastern Denmark From 2013 to 2018 and Was Sometimes Associated With Cannabis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1952-4957","authenticated-orcid":false,"given":"Vibeke","family":"Vestermark","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Naestved, Slagelse, Ringsted Hospitals Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Kj\u00e6rbye\u2010Thygesen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-106X","authenticated-orcid":false,"given":"Ulrik Schi\u00f8ler","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Anbalagan S.","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9010025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600879"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.17269\/s41997\u2010022\u201000726\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2019.305170"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42238\u2010020\u201000047\u20109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.24991"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14850"},{"key":"e_1_2_11_11_1","unstructured":"\u201cStatistics Denmark \u201d 2024 https:\/\/www.statistikbanken.dk\/statbank5a\/selectvarval\/saveselections.asp."},{"key":"e_1_2_11_12_1","unstructured":"Guideline from The Danish Society for Obstetrics and Gynecology \u201cFamilieambulatorie\u2010Guideline; H\u00e5ndtering af Gravide med risikoforbrug af potentielt vanedannende Medicin alkohol eller andre rusmidler \u201d [Family Centre Guideline; Management of Pregnant Women With Risk\u2010Consumption of Potentially Addictive Medicine Alcohol or Other Substances] (In Danish) 2024 https:\/\/static1.squarespace.com\/static\/5467abcce4b056d72594db79\/t\/56547a00e4b00b10016240a6\/1448376832106\/Familieambulatorieguideline+25.03.15.pdf."},{"key":"e_1_2_11_13_1","unstructured":"Guideline from The Danish Pediatric Society \u201cNeonatale Abstinenser [Neonatal Abstinenses] (In Danish) \u201d 2024 https:\/\/paediatri.dk\/images\/dokumenter\/Retningslinjer_2021\/DPS_NAS_11.01.2020.pdf."},{"key":"e_1_2_11_14_1","volume-title":"Current Therapy in Neonatal\u2013Perinatal Medicine","author":"Finnegan L. P.","year":"1990"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001159"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15369"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:25:26Z","timestamp":1775730326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/apa.70443"],"URL":"https:\/\/doi.org\/10.1111\/apa.70443","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"2024-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}