{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:08:18Z","timestamp":1784941698282,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study's aim is to evaluate temporal trends in antimicrobial resistance in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Shigella sonnei<\/jats:italic>\n                      <\/jats:styled-content>\n                      , with a focus on the emergence of ceftriaxone\u2010resistant strains among paediatric patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a 10\u2010year retrospective study of all paediatric patients diagnosed with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Shigella sonnei<\/jats:italic>\n                      <\/jats:styled-content>\n                      via stool culture in our emergency department. Clinical features, laboratory results, and length of hospital stay were reviewed to assess trends in ceftriaxone resistance and compare between resistant and sensitive groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analysed 180 paediatric\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Shigella sonnei<\/jats:italic>\n                      <\/jats:styled-content>\n                      cases. Of these, 177 (98.3%) were tested for ceftriaxone susceptibility: 156 (88.1%) were sensitive, and 21 (11.9%) resistant. Resistant strains emerged in 2022 (85.7%, 6\/7), rising to 88.2% (15\/17) in 2023, showing a strong correlation with calendar year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Resistant cases showed lower neutrophil (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and sodium levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Ceftriaxone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Shigella sonnei<\/jats:italic>\n                      <\/jats:styled-content>\n                      has risen sharply in Israel since 2022, mirroring global trends. This highlights the urgent need for strengthened antimicrobial resistance surveillance and to update current guidelines for the empiric treatment of childhood shigellosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70449","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:54:46Z","timestamp":1768892086000},"page":"1063-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emerging Ceftriaxone Resistance in Paediatric\n                    <scp>\n                      <i>Shigella sonnei<\/i>\n                    <\/scp>\n                    : A 10\u2010Year Retrospective Study"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8581-3142","authenticated-orcid":false,"given":"Antoni","family":"Skripai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Laniado Hospital  Netanya Israel"},{"name":"School of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laniado Hospital  Netanya Israel"},{"name":"School of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lellouche","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Laniado Hospital  Netanya Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Trabelsi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laniado Hospital  Netanya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4811-5432","authenticated-orcid":false,"given":"Nechama","family":"Sharon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laniado Hospital  Netanya Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00203\u2010020\u201002034\u20103"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201057423\u20101"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33296\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003446"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/CLINIDS\/13.SUPPLEMENT_4.S319"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/JAC\/DKZ368"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000475"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010023\u201036222\u20108"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12223\u2010020\u201000773\u2010W\/METRICS"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/CID\/CIAA363"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u20109\u2010204"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00807\u20106"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0219299"},{"key":"e_1_2_12_15_1","unstructured":"\u201cPublic Health Laboratories Jerusalem Yearly Report \u201d(2019) https:\/\/www.gov.il\/BlobFolder\/reports\/lab\u2010jer2019\/he\/files_publications_units_labs_LAB_JER2019.pdf."},{"key":"e_1_2_12_16_1","unstructured":"\u201cPublic Health Laboratories Jerusalem Yearly Report \u201d(2021) https:\/\/www.gov.il\/BlobFolder\/reports\/lab\u2010jer2021\/he\/files_publications_units_labs_lab\u2010jer2021.pdf."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/SPECTRUM.02337\u201021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2024.29.31.2400022"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60844\u20102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0277574"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JIAC.2020.04.022"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.5152\/CED.2015.2076"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/SPECTRUM.01006\u201024"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41579\u2010024\u201001126\u2010X"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/S40249\u2010020\u201000654\u2010X"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.049908"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20103083.2002.01079.X"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.2.5.616\u2010622.1995"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/PED.15792"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0194325"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/CID\/CIAA1545"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:25:43Z","timestamp":1775730343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/apa.70449"],"URL":"https:\/\/doi.org\/10.1111\/apa.70449","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}