{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:40:39Z","timestamp":1783525239202,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated central autonomic network maturation deviations using a previously defined machine learning model set to estimate a functional maturation age (FMA) from heart rate variability (HRV) analysis. We investigated whether these deviations were associated with maternal, fetal, perinatal, or postnatal complications and with neurodevelopment at 2\u2009years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Differences (\u0394HRV) between post\u2010menstrual age (PMA) and FMA were measured in a multicenter prospective cohort of 132 preterm infants born &lt;\u200930\u2009weeks gestational age (GA). The relationship between \u0394HRV and clinical factors, occurrence of complications or alterations in neurodevelopment assessed by Ages and Stages Questionnaire (ASQ) at 2\u2009years of age was studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u0394HRV expressed in weeks delay at 34\u2009weeks of PMA was greater when GA was lower (3 IQR 2.3\u20133.9) at 24\u201326 versus 1.3 (IQR 0.8\u20132.4) at 28\u201330\u2009weeks GA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), in cases of bronchopulmonary dysplasia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) or patent ductus arteriosus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). \u0394HRV was also associated with altered social skills at 2\u2009years of age (OR 2.05, 95% CI 1.02; 4.14 for each week,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) but not with ASQ total score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u0394HRV, early and non\u2010invasively estimated, depends on GA, perinatal and postnatal complications. Its assessment could contribute to evaluation of neurodevelopmental risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70462","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:21:33Z","timestamp":1770884493000},"page":"1191-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Maturation of Heart Rate Variability in Very Preterm Infants Depends on Neonatal Factors and Is Associated With Neurodevelopmental Risk"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2550-4058","authenticated-orcid":false,"given":"L\u00e9a","family":"Bonneau","sequence":"first","affiliation":[{"name":"Department of Paediatrics Rennes University Hospital  Rennes France"},{"name":"Univ Rennes, Inserm  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Flamant","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Esvan","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Center of Clinical Investigation, Inserm Rennes University Hospital  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-7254","authenticated-orcid":false,"given":"Jean Michel","family":"Rou\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neonatology Brest University Hospital  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Favrais","sequence":"additional","affiliation":[{"name":"Department of Neonatology Tours University Hospital  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Gascoin","sequence":"additional","affiliation":[{"name":"Department of Neonatology Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandie","family":"Cabon","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Por\u00e9e","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Carrault","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pladys","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Rennes University Hospital  Rennes France"},{"name":"Univ Rennes, Inserm  Rennes 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