{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:14:54Z","timestamp":1778944494197,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To identify clinical and laboratory factors associated with egg allergy persistence beyond age 8 in children diagnosed within the first 2\u2009years of life.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively analysed 77 children with IgE\u2010mediated egg allergy (2013\u20132024). Patients were classified into persistent (\n n<\/jats:italic>\n \u2009=\u200912) and tolerance (\n n<\/jats:italic>\n \u2009=\u200965) groups after at least 8\u2009years of follow\u2010up. Multivariable logistic regression was performed to identify independent predictors.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Persistence beyond age 8 occurred in 12 patients (15.6%). Multivariable analysis identified diagnosis at \u2264\u20095\u2009months (OR 21.37), multiple food allergies (OR 8.47), and higher baseline egg\u2010white specific IgE (F1) levels (OR 1.09 per 1 kU\/L rise) as independent risk factors. The area under the curve (AUC) for initial F1 levels was 0.896 (95% CI: 0.808\u20130.985). A combined multivariable model incorporating diagnosis age, multiple food allergies, and initial F1 levels demonstrated superior predictive performance with an AUC of 0.935 (95% CI: 0.861\u20130.999).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Early diagnosis, multiple food allergies, and high baseline specific IgE levels are strong predictors of egg allergy persistence beyond age 8. These factors enable clinicians to stratify high\u2010risk patients and tailor long\u2010term management strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apa.70490","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:32:09Z","timestamp":1773001929000},"page":"1274-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated With Egg Allergy Persistence Beyond 8\u2009Years of Age"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-7759","authenticated-orcid":false,"given":"Yasemin","family":"Tepe","sequence":"first","affiliation":[{"name":"Department of Pediatric Immunology and Allergy University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0330-1146","authenticated-orcid":false,"given":"\u0130dan F\u0131rat","family":"Unay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-4218","authenticated-orcid":false,"given":"Zeynep Ef\u015fan Ba\u015fer","family":"Sinoplu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-6749","authenticated-orcid":false,"given":"Kaz\u0131m Okan","family":"Dolu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-5445","authenticated-orcid":false,"given":"Himmet Haluk","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital Istanbul 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