{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T17:07:21Z","timestamp":1782580041717,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Caffeine is the mainstay of treatment for apnea of prematurity, yet the optimal strategy and timing for discontinuation remain undefined. Marked inter\u2010centre variation in the practise of discharging preterm infants home on caffeine therapy has been reported. We aimed to map current practises in Europe concerning discharge of preterm infants on caffeine therapy, including home\u2010monitoring and strategies for discontinuing ambulatory therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A web\u2010based three\u2010part questionnaire was sent to 633 neonatal units in 36 European countries (July\u2013October\u20092025). One response per unit was permitted. The survey collected data on policies and practises regarding discharge on caffeine, criteria for stopping therapy, and post\u2010discharge monitoring. Responses were analysed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete responses were obtained from 125\u2009units in 21, revealing wide variation in practise patterns. Fifty\u2010eight per cent of participating centres reported discharging preterm infants on continued caffeine therapy at least occasionally. Among those units, 58% reported prescribing home\u2010monitoring routinely for infants discharged on caffeine therapy. Overall, significant differences in practise existed between geographical regions but not between high\u2010 and low\u2010volume centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Discharging preterm infants on continued caffeine therapy is a widespread practise among neonatologists in Europe, with considerable variation among regions and differing strategies concerning home\u2010monitoring and discontinuation of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70502","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:22:19Z","timestamp":1773476539000},"page":"1437-1443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discharging Preterm Infants on Caffeine\u2014Practise Variation Across Europe: Results of a Cross\u2010Sectional Survey"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-2838","authenticated-orcid":false,"given":"Martin","family":"Kuntz","sequence":"first","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-3125","authenticated-orcid":false,"given":"Lina","family":"Raljevic","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3091-8290","authenticated-orcid":false,"given":"Daniel","family":"Matheisl","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5199-0266","authenticated-orcid":false,"given":"Hendryk","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-3699","authenticated-orcid":false,"given":"Hans","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054065"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0238"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010025\u201004387\u20101"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.4371"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.023432"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01943.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.72"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101177"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-15814077"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2006.06.016"},{"issue":"9","key":"e_1_2_13_12_1","article-title":"Discharging 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