{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:49:49Z","timestamp":1784612989161,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The prevalence of food allergy has increased in recent decades. We aimed to determine the cumulative incidence of food allergy in early childhood and to identify associated risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective birth cohort study including 1006 newborns recruited over one year at a single hospital in Spain and followed until 4\u2009years of age. Data were collected at birth and through structured telephone interviews during follow\u2010up. Children with suspected food allergy underwent skin prick testing, specific serum IgE measurement and open oral food challenges when indicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative incidence of food allergy was 7.2% (72\/1006). Independent risk factors for IgE\u2010mediated food allergy included hospitalization for bronchospasm (adjusted odds ratio [aOR] 2.37; 95% CI 1.07\u20135.26), atopic dermatitis (aOR 7.52; 95% CI 3.77\u201315.01), maternal asthma (aOR 3.12; 95% CI 1.30\u20137.53) and paternal allergic rhinitis (aOR 2.79; 95% CI 1.31\u20135.94). Proton\u2010pump inhibitor use, absence of daycare attendance and early\u2010onset atopic dermatitis were associated with non\u2010IgE\u2010mediated food allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this Spanish birth cohort, food allergy affected 7.2% of children by age 4. Atopic dermatitis was the main risk factor for IgE\u2010mediated food allergy, while potentially modifiable early\u2010life exposures were associated with non\u2010IgE\u2010mediated forms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70530","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:50:49Z","timestamp":1776343849000},"page":"1654-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence and Early\u2010Life Risk Factors for Food Allergy in a Spanish Birth Cohort"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-5638","authenticated-orcid":false,"given":"Jorge","family":"Garc\u00eda\u2010Ezquiaga","sequence":"first","affiliation":[{"name":"Pediatric Department Severo Ochoa University Hospital  Legan\u00e9s Madrid 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