{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:08:21Z","timestamp":1784308101079,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether early lactate dehydrogenase (LDH) and amplitude\u2010integrated electroencephalography (aEEG) improve the prediction of outcome in outborn infants transported for therapeutic hypothermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Secondary analysis of a randomised controlled trial (2016\u20132019) including 113 asphyxiated newborn infants randomised to transport with a phase\u2010change material mattress or standard care. The analysis included 81 infants with available aEEG, of whom 50 had LDH measured on admission. Outcome at 18\u2009months was categorised as good, defined as normal development or mild delay, or poor, defined as moderate or severe impairment or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Mean (SD) rectal temperature on admission was lower in the PCM group (34.6 [1.1]\u00b0C vs. 35.2 [1.1]\u00b0C,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), but the proportion within target temperature did not differ (39.5% vs. 25.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.235). Clinical characteristics, LDH, aEEG and outcomes were similar between groups. Poor outcome was predicted by LDH\u2009&gt;\u20091000\u2009U\/L (89% sensitivity and 61% specificity), severely depressed aEEG within 12\u2009h (87% sensitivity and 47% specificity) and the combination of both (91% sensitivity, 62% specificity and accuracy 81%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined LDH and aEEG provide a strong early prediction of outcome in encephalopathic infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70556","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:37:08Z","timestamp":1777541828000},"page":"1746-1754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude\u2010Integrated\n                    <scp>EEG<\/scp>\n                    in Transported Newborn Infants with Hypoxic\u2013Ischaemic Encephalopathy"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0254-2535","authenticated-orcid":false,"given":"Hang T. T.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Global Public Health Karolinska Institutet  Stockholm Sweden"},{"name":"Neonatal Care Center Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha T.","family":"Le","sequence":"additional","affiliation":[{"name":"Neonatal Care Center Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dien M.","family":"Tran","sequence":"additional","affiliation":[{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Alfv\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Global Public Health Karolinska Institutet  Stockholm Sweden"},{"name":"Sach's Children's Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-6348","authenticated-orcid":false,"given":"Linus","family":"Olson","sequence":"additional","affiliation":[{"name":"Neonatal Care Center Vietnam National Children's Hospital  Hanoi Vietnam"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-6069","authenticated-orcid":false,"given":"Lena","family":"Hellstrom\u2010Westas","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.206"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-17"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0456"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00264-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15331"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010024\u201004987\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2024.106189"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F34"},{"issue":"2","key":"e_1_2_11_10_1","first-page":"144","article-title":"Evaluation of Lactate Dehydrogenase, Creatine Kinase and Hepatic Enzymes for the Retrospective Diagnosis of Perinatal Asphyxia Among Sick Neonates","volume":"45","author":"Reddy S.","year":"2008","journal-title":"Indian Pediatrics"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01802.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2023-002208"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.7-2-e76"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182872b24"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1205022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/00050551"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165744"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1208745"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12964"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02778.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.05.008"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:44:21Z","timestamp":1784306661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/apa.70556"],"URL":"https:\/\/doi.org\/10.1111\/apa.70556","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}