{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:50:04Z","timestamp":1791881404466,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024017","name":"Sheba Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Paediatric cancer survivors often experience treatment\u2010induced immunosuppression, requiring post\u2010treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute\u2010lymphoblastic\u2010leukaemia (ALL), may not be applicable across all paediatric malignancies. This study evaluated a personalised revaccination approach based on immune recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immune recovery was evaluated using antibody titers to common childhood vaccines, immunoglobulin levels, B\u2010 and T\u2010cell subpopulations, and T\u2010cell receptor excision circles (TREC) and kappa\u2010deleting recombination excision circles (KREC) markers. The recommended revaccination window was defined as 3\u20136\u2009months post\u2010treatment. Patients completing immune and serology testing within this window were categorised as the per\u2010protocol\u2010group (PPG), while others were categorised as the protocol\u2010deviated\u2010group (PDG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 19 PPG patients, 57.9% required major and 36.8% minor modifications to recommended revaccination guidelines, with major modifications more common among hematologic malignancies than solid tumours (83.3% vs. 46.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In the intention\u2010to\u2010treat (ITT) cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952), 40.4% required major and 57.7% minor modifications; hematologic survivors again had higher rates of major modifications (52.9% vs. 34.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immune recovery following paediatric cancer therapy is highly variable, particularly among hematologic malignancies. Personalised revaccination strategies incorporating comprehensive immunological workups may optimise protection against vaccine\u2010preventable diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70559","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:38:26Z","timestamp":1777106306000},"page":"2603-2615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors"],"prefix":"10.1111","volume":"115","author":[{"given":"Menucha","family":"Jurkowicz","sequence":"first","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Dresner","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Paret","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Boston Children's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Katzenellenbogen","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Gelman","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Asraf","sequence":"additional","affiliation":[{"name":"The Dworman Automated\u2010Mega Laboratory, Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Doolman","sequence":"additional","affiliation":[{"name":"The Dworman Automated\u2010Mega Laboratory, Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atar","family":"Lev","sequence":"additional","affiliation":[{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Pediatric Department A, Immunology Service and Lab Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-4122","authenticated-orcid":false,"given":"Amos J.","family":"Simon","sequence":"additional","affiliation":[{"name":"School of Medicine, Grey Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Pediatric 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