{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:38:01Z","timestamp":1792615081655,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR153425"],"award-info":[{"award-number":["NIHR153425"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early\u2010onset Group B Streptococcus (EOGBS) and identify gaps in short and longer\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010phase rapid review. Phase 1 included an overview of systematic reviews (SRs). Phase 2 identified primary studies from SRs supplemented by additional searches. Outcomes included screening effectiveness, maternal and neonatal health outcomes and reported harms or benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phase 1 identified three moderate\u2010high quality reviews; 78 primary studies met phase 2 eligibility criteria. Any prevention strategy reduced EOGBS incidence, all\u2010cause early\u2010onset sepsis (EOS) and EOGBS\u2010related mortality compared to no strategy. Universal screening was more effective in reducing EOGBS and all\u2010cause EOS compared with risk\u2010based approaches, with no evidence of any difference between the approaches for non\u2010GBS EOS incidence or EOGBS\u2010related mortality. Evidence was low to very\u2010low certainty. Other neonatal outcomes (meningitis, pneumonia, late\u2010onset GBS or maternal outcomes) were limited. Long\u2010term child outcomes were under\u2010reported. Few studies reported women's views. Protocol violations and missed opportunities were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Any prevention strategy reduces the incidence of EOGBS, all\u2010cause EOS and EOGBS\u2010related mortality compared to no strategy. Differences between universal and risk\u2010based approaches remain unclear. Improved reporting, longer\u2010term evaluation and implementation\u2010focused research are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70568","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:35:16Z","timestamp":1777566916000},"page":"1598-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Benefits and Harms of Antenatal\/Intrapartum Screening for Maternal\n                    <scp>Group B Streptococcus<\/scp>\n                    and Use of Intrapartum Antibiotic Prophylaxis Versus Risk\u2010Based Protocols or No Intervention: A Rapid Review"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-5526","authenticated-orcid":false,"given":"Pauline","family":"Campbell","sequence":"first","affiliation":[{"name":"Research Centre for Health (ReaCH) Department of Nursing, Community and Public Health, School of Health and Life Sciences Glasgow Caledonian University  Glasgow Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-1394","authenticated-orcid":false,"given":"Cathryn","family":"Broderick","sequence":"additional","affiliation":[{"name":"NESSIE\u2014NIHR Evidence Synthesis Scotland InitiativE, Usher Institute, Usher Building The University of Edinburgh  Edinburgh Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candida","family":"Fenton","sequence":"additional","affiliation":[{"name":"NESSIE\u2014NIHR Evidence Synthesis Scotland InitiativE, Usher Institute, Usher Building The University of Edinburgh  Edinburgh Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Davis","sequence":"additional","affiliation":[{"name":"Research Centre for Health (ReaCH) Department of Nursing, Community and Public Health, School of Health and Life Sciences Glasgow Caledonian University  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