{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:41:24Z","timestamp":1786470084592,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011566","name":"Marga und Walter Boll-Stiftung","doi-asserted-by":"publisher","award":["210\u201001.01\u201019"],"award-info":[{"award-number":["210\u201001.01\u201019"]}],"id":[{"id":"10.13039\/501100011566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To describe changes in peripheral oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) and regional cerebral oxygenation (rcSO\n                      <jats:sub>2<\/jats:sub>\n                      ) during less invasive surfactant administration (LISA) in a high\u2010level continuous positive airway pressure (CPAP) respiratory support delivery room protocol in very low birth weight infants (VLBW).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a secondary analysis of data from the randomized\u2010controlled Extrauterine Placental Transfusion in Resuscitation of VLBW infants (EXPLAIN) trial. In total, 38 patients were included. The pressure and changes in heart rate, SpO\n                      <jats:sub>2<\/jats:sub>\n                      and rcSO\n                      <jats:sub>2<\/jats:sub>\n                      were assessed 10\u2009min before until 10\u2009min after the LISA procedure. Basic outcome data for the patient collective were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean gestational age was 27 + 6\u2009weeks (\u00b115\u2009days), and mean birth weight was 995.8\u2009g (\u00b1298.8). All infants were eligible for LISA. During LISA, heart rate, SpO\n                      <jats:sub>2<\/jats:sub>\n                      and rcSO\n                      <jats:sub>2<\/jats:sub>\n                      decreased significantly (mean change 32.4 (\u00b1\u200927.5) bpm, \u221214.5 (\u00b1\u200910.7) % and \u221211.9 (\u00b1\u20099.1) %, respectively; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Moreover, two infants developed a pneumothorax and three infants required endotracheal intubation within 72\u2009h after birth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With the approach of a high\u2010level CPAP setting, we observed transient decreases in heart rate and oxygenation levels during LISA. The magnitude of these decreases was within the expected or potentially favourable range compared with prior studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier:NCT03916159<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70591","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:20:48Z","timestamp":1778822448000},"page":"1953-1958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Oxygen Saturation During Less\u2010Invasive Surfactant Administration Using a High\u2010Pressure\n                    <scp>CPAP<\/scp>\n                    Respiratory Support Delivery Room Protocol\u2014A Cohort Study"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9382-3538","authenticated-orcid":false,"given":"Jan","family":"Trieschmann","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kribs","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne 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