{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:11:00Z","timestamp":1788883860623,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Research on the drug delivery of inhaled corticosteroids and combination medications via valved holding chambers (VHCs) with children's breathing patterns is limited. We aimed to evaluate the in\u00a0vitro performance of commercially available VHCs without facemasks under preschooler breathing conditions, focusing on total delivered dose and fine particle dose (FPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the FPD in 1\u20135\u2009\u03bcm range of fluticasone\/salmeterol combination inhaler, fluticasone propionate mono\u2010inhaler, and ciclesonide delivered through three VHCs: AeroChamber Plus Flow\u2010Vu, EasyChamber, and OptiChamber Diamond. Drug delivery was measured using a Next Generation Impactor with simulated breathing representative of a 4\u2010year\u2010old child.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total delivered dose compared to the label claim was highest for ciclesonide with all the VHCs. The median FPD in 1\u20135\u2009\u03bcm range was significantly higher with EasyChamber compared to AeroChamber and OptiChamber for salmeterol and fluticasone from combination\u2010inhaler and ciclesonide. Overall, relative throat deposition was lowest for ciclesonide and highest for fluticasone mono\u2010inhaler. OptiChamber yielded lowest relative throat depositions for ciclesonide and fluticasone mono\u2010inhaler, while EasyChamber gave lowest relative throat depositions for salmeterol and fluticasone from combination inhaler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were notable differences between the tested VHC's drug delivery. Ciclesonide exhibited favourable aerodynamic properties than fluticasone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70622","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:54:41Z","timestamp":1780401281000},"page":"2159-2167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy"],"prefix":"10.1111","volume":"115","author":[{"given":"Laura","family":"Ojanper\u00e4","sequence":"first","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Allergy Centre Tampere University Hospital  Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0819-7875","authenticated-orcid":false,"given":"P\u00e9ter","family":"Csonka","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02866\u20102021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2004.00526.x"},{"key":"e_1_2_11_4_1","unstructured":"Global Initiative for Asthma \u201cGlobal Strategy for Asthma Management and Prevention \u201d(2025) accessed January 19 2026 http:\/\/www.ginasthma.org."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2021.42.210085"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2021.42.210062"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.034"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/002013240004500608"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.10.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010021\u201004074\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27300"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.515603"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00050\u20102021"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00166410"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)62226\u2010X"},{"issue":"76","key":"e_1_2_11_16_1","first-page":"576","article-title":"Breathing Patterns","volume":"10","author":"Nikander K.","year":"2000","journal-title":"European Respiratory Review"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05501191"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1995.8.Suppl_3.S\u20103"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.02.010"},{"key":"e_1_2_11_20_1","first-page":"877","article-title":"In Vitro Performance of Fluticasone\/Salmeterol Pressurized Metered Dose Inhaler in Combination With Three Different Valved Holding Chambers","volume":"31","author":"Goncalves T. 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