{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:10:17Z","timestamp":1788883817261,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Bronchiolitis is a major cause of hospitalisation in young children, but the effectiveness of inhaled hypertonic saline remains unclear. We compared treating hospitalised infants with nebulised hypertonic saline or normal saline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This multisite, double\u2010blind RCT was conducted from 1 October 2023 to 1 April 2025 in four Polish paediatric units. Children from 5\u2009weeks to 24\u2009months, who had been hospitalised with mild\u2010to\u2010moderate bronchiolitis, were randomly assigned to receive nebulised 3% hypertonic saline or 0.9% normal saline until discharge. They were followed for 7\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study comprised 181 children (55% male) with a mean age of 8.3\u2009\u00b1\u20096.3\u2009months: 90 were randomised to hypertonic saline and 91 to normal saline. The median hospital stay was 2.68 (1.92\u20134.03) days in the hypertonic saline group and 2.79 (1.8\u20133.96) days in the normal saline group. The mean difference was \u22120.11\u2009days (95% confidence interval \u22120.73 to 0.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3). No differences were observed in clinical severity scores between the groups. Readmissions only occurred in the normal saline group (5.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypertonic saline inhalation did not reduce the length of hospital stay or improve clinical severity scores in hospitalised children with bronchiolitis, but it was associated with a lower risk of rehospitalisation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70632","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:01:41Z","timestamp":1780549301000},"page":"2209-2217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomised, Multicentre Clinical Trial Found That Hypertonic Saline Did Not Reduce the Length of Stay of Hospitalised Patients With Acute Bronchiolitis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0270-6080","authenticated-orcid":false,"given":"Sara","family":"Szupie\u0144ko\u2010Bujak","sequence":"first","affiliation":[{"name":"Department of Paediatrics St Hedwig of Silesia Hospital  Trzebnica Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9516-2903","authenticated-orcid":false,"given":"Karolina","family":"Bojarska\u2010Cikoto","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wroclaw Medical University  Wa\u0142brzych Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Merdzik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Brzeg Medical Center  Brzeg Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Bogoryja\u2010Zakrzewska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2624-7110","authenticated-orcid":false,"given":"Aleksandra","family":"Sukiennik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Hedwig of Silesia Hospital  Trzebnica Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Pietraszewska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Hedwig of Silesia Hospital  Trzebnica Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wroclaw Medical University  Wa\u0142brzych Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-4781","authenticated-orcid":false,"given":"Waldemar","family":"Go\u0142\u0119biowski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wroclaw Medical University  Wa\u0142brzych Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-7748","authenticated-orcid":false,"given":"Henryk","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Hedwig of Silesia Hospital  Trzebnica Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01016\u20109"},{"key":"e_1_2_11_3_1","unstructured":"NICE \u201cBronchiolitis in Children: Diagnosis and Management \u201d London: National Institute for Health and Care Excellence (NICE) 2021. (NICE Guideline No. 9) https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK573086\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006458.pub5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010020\u201002314\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7684"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20101914"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0681"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0079"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102020\u2010319048"},{"key":"e_1_2_11_11_1","first-page":"A108","article-title":"G297(P) Hypertonic Saline\u2013An Option for Treatment of Bronchiolitis\u2013A Literature Review","volume":"105","author":"Kamal M.","year":"2020","journal-title":"Archives of Disease in Childhood"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010080182"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102024\u2010081123"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20100938"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1937"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23750"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.5155"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:48:53Z","timestamp":1788882533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/apa.70632"],"URL":"https:\/\/doi.org\/10.1111\/apa.70632","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}