{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:10:14Z","timestamp":1788883814991,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["0176\u201000020B"],"award-info":[{"award-number":["0176\u201000020B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim was to investigate the incidence of sepsis and use of antibiotics among extremely preterm infants, given the limited number of population\u2010based studies examining this.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study in Eastern Denmark included all liveborn infants from 23\u2009+\u20090\u2009weeks\/days to 27\u2009+\u20096\u2009weeks\/days of gestation from 2019 to 21. Data on dispensed intravenous antibiotics were obtained from the regional joint electronic health platform. Early\u2010onset sepsis was defined as occurring within the first 72\u2009h of life and late\u2010onset sepsis from 3 to 90\u2009days. Positive blood culture episodes were classified as proven sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the first six months of life, 187 of the 232 (81%) infants received intravenous antibiotics. Empirical treatment was initiated for early\u2010onset sepsis in 164 of the 232 infants (71%) and late\u2010onset sepsis in 118 (51%). Late\u2010onset sepsis accounted for 90% of proven sepsis, predominantly caused by\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      <\/jats:styled-content>\n                      and Coagulase\u2010negative\n                      <jats:italic>Staphylococcus.<\/jats:italic>\n                      Antibiotic use for late\u2010onset sepsis was three\u2010fold higher than for early\u2010onset sepsis (9902 versus 3413\u2009days per 1000 live births). Sepsis caused two deaths (9 per 1000 live births infants).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suspected early\u2010onset sepsis was the most common indication for antibiotic initiation, but late\u2010onset accounted for most proven sepsis episodes and antibiotic exposure in extremely preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70637","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:09:37Z","timestamp":1780999777000},"page":"2228-2236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late\u2010Onset Sepsis Accounted for Most Cases and Antibiotic Use"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7782-3589","authenticated-orcid":false,"given":"Anna Bjerager","family":"Arnesen","sequence":"first","affiliation":[{"name":"Department of Neonatology Copenhagen University  Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nini","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Copenhagen University  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Dyrberg","family":"Vibede","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University  Herlev 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