{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:41:53Z","timestamp":1793752913874,"version":"4.6.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the proportion of children with Down syndrome (DS) with creatinine levels above standard paediatric reference ranges in a single\u2010centre Irish outpatient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cross\u2010sectional study of children aged 0\u201316\u2009years attending the DS Clinic at Children's Health Ireland, Tallaght, between June 2022 and June 2024. Children with known renal disease and acute results were excluded. Creatinine levels were analysed using age\u2010 and sex\u2010specific reference ranges. The proportion with creatinine above the upper reference limit was compared with the expected proportion of 2.5% using a one\u2010sided exact binomial test. Estimated glomerular filtration rate (eGFR) was calculated using the bedside Schwartz equation, where height was available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 194 patients were included. Among them, 52 (26.8%) had creatinine levels above the upper reference limit (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Additionally, 42 (21.6%) had persistently elevated creatinine (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Height was available for 124 children. Of those, 42 (34%) had an eGFR &lt;\u200990\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      and 1 (0.8%) had an eGFR &lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with DS in this Irish clinic frequently had creatinine levels above standard reference ranges. Further studies are required to clarify the clinical significance of these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70640","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:15:31Z","timestamp":1781694931000},"page":"1883-1890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Creatinine Levels in Children With Down Syndrome: A Single\u2010Centre Retrospective Study in Ireland"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8675-8135","authenticated-orcid":false,"given":"C.","family":"Broderick Farrell","sequence":"first","affiliation":[{"name":"Department of Child Development and Neurodisability Children's Health Ireland, Tallaght  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Peronace","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity College, the University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Independent Researcher (Medical Statistics Support)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"McGrane","sequence":"additional","affiliation":[{"name":"Department of Child Development and Neurodisability Children's Health Ireland, Tallaght  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Molloy","sequence":"additional","affiliation":[{"name":"Department of Child Development and Neurodisability Children's Health Ireland, Tallaght  Dublin Ireland"},{"name":"School of Medicine, Trinity College, the University of Dublin  Dublin Ireland"},{"name":"Department of Neonatology The Coombe Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Riordan","sequence":"additional","affiliation":[{"name":"School of Medicine Royal College of Surgeons in Ireland  Dublin Ireland"},{"name":"Department of Nephrology Children's Health Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-6584","authenticated-orcid":false,"given":"J.","family":"Balfe","sequence":"additional","affiliation":[{"name":"Department of Child Development and Neurodisability Children's Health Ireland, Tallaght  Dublin Ireland"},{"name":"School of Medicine, Trinity College, the University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Down Syndrome Ireland Facts about Down syndrome [Internet] 2019Available from https:\/\/downsyndrome.ie\/facts\u2010about\u2010down\u2010syndrome\/."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15119"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009\u20100181"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36780"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.11.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010005\u20101819\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.14376"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010022\u201005477\u2010z"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070401"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010057010"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108749.2004.tb00480.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19779"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010024\u201005378\u2010z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2011.02.023"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36337"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010021\u201004069\u20104"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/labmed.2002.039"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640309"}],"container-title":["Acta 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