{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:10:14Z","timestamp":1788883814965,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between serum ALP levels and the development of AKI in paediatric patients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective screening of a computerized database of 4 Israeli regional hospitals for children (0\u201318\u2009years) hospitalized between 1.01.2000\u20131.06.2024 with ICD\u20109 sepsis\u2010related diagnoses (study group) and age\u2010 and sex\u2010matched non\u2010septic febrile patients (controls). Serum ALP levels were sex\u2010 and age\u2010adjusted and described as standard deviation scores (SDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 809\u2009952 screened hospitalizations, 701 records comprised the study group. Their median (IQR) age was 17 (10\u201338) months, 53% were males. Nadir ALP\u2010SDS was lower in the sepsis group compared to controls (\u22121.65\u2009\u00b1\u20091.11 vs. \u22120.97\u2009\u00b1\u20091.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and further lower in those with AKI, which occurred in 23% of the sepsis cohort (\u22121.95\u2009\u00b1\u20091.16 vs. \u22121.56\u2009\u00b1\u20091.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Hospital stay was longer in the AKI compared to non\u2010AKI group [median (IQR): 7 (4, 12) vs. 4 (3, 5) days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. Lower ALP\u2010SDS was independently associated with AKI [OR (95% CI): 0.7 (0.6\u20130.8),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001], after controlling for CRP and leucocyte count.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ALP was lower in sepsis patients compared to controls, and significantly lower in AKI vs. non\u2010AKI group, suggesting it as an additional marker of infection severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70665","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:19:04Z","timestamp":1782710344000},"page":"2315-2322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Serum Alkaline Phosphatase Levels in Paediatric sepsis Correlate With Acute Kidney Injury: A Multicenter Retrospective Study"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-362X","authenticated-orcid":false,"given":"Evgenia","family":"Gurevich","sequence":"first","affiliation":[{"name":"Department of Pediatrics Barzilai University Medical Center  Ashkelon Israel"},{"name":"Faculty of Health Sciences Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Barzilai University Medical Center  Ashkelon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehonatan","family":"Marziano","sequence":"additional","affiliation":[{"name":"The Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kalinin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Barzilai University Medical Center  Ashkelon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Bilenko","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben Gurion University of the Negev  Beer Sheva Israel"},{"name":"Medical Office of Ashkelon District, Ministry of Health  Ashkelon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Landau","sequence":"additional","affiliation":[{"name":"Nephrology Institute, Schneider Children's Medical Center  Petah Tikva Israel"},{"name":"Gray School of Medicine Tel Aviv University  Tel Aviv 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