{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:10:22Z","timestamp":1788883822030,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Childhood ischemic stroke is rare but causes substantial long\u2010term morbidity, and its heterogeneous aetiology complicates timely diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective population\u2010based observational study using hospital data and chart review to describe diagnostics, treatment and outcomes of ischemic stroke in patients aged 1\u2009month to 18\u2009years treated at HUS Helsinki University Hospital between 2010 and 2023. Hemorrhagic strokes were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 137 patients, the median annual incidence was 2.5 per 100\u2009000 children. The five largest aetiological subgroups were idiopathic (18%), arteriopathy (16%), major surgery (13%), cardiac embolism (13%) and infection (12%). More than half of patients with available data were diagnosed more than 24\u2009h after symptom onset. Hemiplegia was the most frequent symptom (44%), followed by seizures (25%), which were particularly common in infants. At follow\u2010up, about half of the patients had motor and\/or neuropsychological deficits. Epilepsy developed in 20 (15%) patients and recurrent stroke occurred in 8 (6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Childhood ischemic strokes in our population had heterogeneous causes and substantial long\u2010term morbidity. Diagnostic delays were frequent, underscoring the need to improve recognition of paediatric stroke. The low recurrence rate highlights the importance of population\u2010specific factors when interpreting risk and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70667","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:34:09Z","timestamp":1782938049000},"page":"2332-2340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population\u2010Based Study From Southern Finland"],"prefix":"10.1111","volume":"115","author":[{"given":"Jussi V.","family":"Leinonen","sequence":"first","affiliation":[{"name":"Bayer Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samu","family":"Kurki","sequence":"additional","affiliation":[{"name":"Bayer Oy  Espoo 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