{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:31:30Z","timestamp":1786343490483,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare safety and clinical outcomes of two different oral immunotherapy (OIT) maintenance doses (150\u2009mg vs. 300\u2009mg) of peanut protein in children with peanut allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled 44 children aged 4\u201317\u2009years with confirmed peanut allergy. Following dose escalation, participants were allocated to receive either 150 or 300\u2009mg of peanut protein daily for 8\u2009weeks. Oral food challenges (OFCs) were conducted before and after OIT. The primary endpoint was the proportion of participants tolerating \u2265\u2009300\u2009mg of peanut protein post\u2010treatment. Secondary outcomes included changes in immunologic markers (skin prick tests wheal size, sIgE, IgG4) and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 44 enrolled children, 33 (75.0%) completed the full protocol. The primary outcome was achieved in 73.9% of the 150\u2009mg group and 71.4% of the 300\u2009mg group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.853). Both regimens were associated with reductions in immunological parameters. Adverse events were mainly mild to moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peanut OIT using either 150\u2009mg or 300\u2009mg maintenance doses was associated with increased tolerance thresholds and immunological changes in highly allergic children. These findings support the feasibility of OIT in real\u2010world clinical settings while highlighting the need for further multicentre research to determine optimal dosing strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70704","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:32:21Z","timestamp":1785940341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Clinical Outcomes of High\u2010 Versus Low\u2010Dose Oral Peanut Immunotherapy in Polish Children With Peanut Allergy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2226-3509","authenticated-orcid":false,"given":"Klementyna","family":"\u0141y\u017cwa","sequence":"first","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-104X","authenticated-orcid":false,"given":"Katarzyna","family":"Grzela","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw 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