{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:37:05Z","timestamp":1790980625019,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe age\u2010specific clinical features and identify predictors of length of hospital stay in children and adolescents with primary Epstein\u2013Barr virus (EBV) infectious mononucleosis (IM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicentre retrospective cohort study included all children and adolescents aged 0\u201317\u2009years with a verified primary EBV infection in the\n                      <jats:italic>Central Denmark Region<\/jats:italic>\n                      between March 2020 and March 2025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1657 serologically verified primary EBV infections, 307 patients (18.5%) required EBV\u2010related hospitalisation. Hospitalisation incidence increased with age. Although adolescents accounted for most EBV\u2010related admissions (77.5%), EBV\u2010infected children below 7\u2009years were hospitalised more often (one in four) than children aged 7\u2009years or older (one in seven). The most common presenting symptoms were tonsillitis (77%), fever (75%) and lymphadenopathy (64%). Hepatic dysfunction was frequent, particularly among adolescents, whereas anaemia and hyperbilirubinemia occurred more often in younger children. Prolonged length\u2010of\u2010stay was independently associated with hyperbilirubinemia, elevated C\u2010reactive protein, organomegaly and secondary bacterial infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Disease severity in paediatric EBV infection was associated with inflammatory and hepatic complications rather than age. Early identification of these features may support risk stratification and optimise inpatient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70707","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:34:17Z","timestamp":1787207657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Predictors of Hospital Stay in Paediatric Epstein\u2013Barr Virus Infectious Mononucleosis: A Multicentre Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3638-2765","authenticated-orcid":false,"given":"Lasse H.","family":"Nyhegn","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Yde","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Regional Hospital Randers  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine Fr\u00f8lich","family":"Maarbjerg","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Regional Hospital Randers  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-0601","authenticated-orcid":false,"given":"Luise","family":"Borch","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-6689","authenticated-orcid":false,"given":"Marianne Kragh","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Microbiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-4056","authenticated-orcid":false,"given":"Mette","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus 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