{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:08:12Z","timestamp":1788926892508,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Component\u2010resolved diagnostics (CRD) improve diagnosis and risk stratification in peanut allergy. We evaluated the diagnostic performance of five recombinant peanut allergens for predicting peanut\u2010induced anaphylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 164 children with peanut sensitization and elevated IgE to recombinant allergens. Patients were classified as Group A (no\/mild symptoms) or Group B (anaphylaxis). Specific IgE levels were compared, ROC curves identified optimal cut\u2010offs, and odds ratios were estimated using Firth penalized logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ara h 1\u2010, Ara h 2\u2010 and Ara h 3\u2010specific IgE levels were significantly higher in Group B. The strongest association was observed for Ara h 2 (OR 19.65, 95% CI 5.83\u201372.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), followed by Ara h 3 (OR 7.27, 95% CI 2.31\u201326.34;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and Ara h 1 (OR 6.21, 95% CI 1.77\u201320.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Ara h 8 was not associated with anaphylaxis, whereas Ara h 9 showed an inverse association (OR 0.23, 95% CI 0.06\u20130.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Optimal cut\u2010offs were Ara h 1\u2009\u2265\u20092.60, Ara h 2\u2009\u2265\u200910.36 and Ara h 3\u2009\u2265\u20090.18 kUA\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific IgE to Ara h 1, Ara h 2 and Ara h 3, particularly Ara h 2, was associated with peanut\u2010induced anaphylaxis. The proposed cut\u2010offs require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70728","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:52:39Z","timestamp":1788925959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of Recombinant Peanut Allergens in Children:\n                    <scp>sIgE<\/scp>\n                    Cut\u2010Offs and Anaphylaxis Risk"],"prefix":"10.1111","author":[{"given":"Lisa","family":"Gazzolari","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[{"name":"Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Prevention of Human Sciences and Promotion of the Quality of Life  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"D'Andrea","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"},{"name":"Maternal and Child Health Unit Local Health Authority of Rieti (ASL Rieti)  Rieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sala","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pizzoli","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Unit Local Health Authority of Rieti (ASL Rieti)  Rieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Faraoni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology San Camillo De Lellis Hospital  Rieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Hoxha","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Di Pillo","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-3160","authenticated-orcid":false,"given":"Marina","family":"Attanasi","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.jaci.2010.03.015","article-title":"A Population\u2010Based Study on Peanut, Tree Nut, Fish, Shellfish, and Sesame Allergy Prevalence in Canada","volume":"125","author":"Ben\u2010Shoshan M.","year":"2010","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.jaci.2010.03.029","article-title":"US Prevalence of Self\u2010Reported Peanut, Tree Nut, and Sesame Allergy: 11\u2010Year Follow\u2010Up","volume":"125","author":"Sicherer S. 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