{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:13:45Z","timestamp":1788599625854,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine growth patterns and catch up potential in children with biliary atresia, in relation to liver disease severity and liver transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted at Copenhagen University Hospital between 1 January 2006 and 31 December 2024 and included 63 children. Anthropometry and paraclinical liver tests were assessed every 3\u2009months until age 2, and every 6\u2009months thereafter until age 18. Mixed linear models with 95% CI were used to assess anthropometry over time and its association with blood liver markers. Blood test variables were displayed in association with insulin\u2010like growth factor\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children with biliary atresia reached their age\u2010specific height\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      score after 7\u20138.5\u2009years and catch\u2010up growth lasted twice as long in those liver transplanted before versus after 2\u2009years of age. Paraclinical liver parameters were shown to be correlated with weight\u2010for\u2010height and height\u2010for\u2010age in biliary children with and without a liver transplant. Results on IGF\u20101 revealed no association with paraclinical liver tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with biliary atresia have the potential to catch up in growth with their age\u2010specific height and weight. Paraclinical liver tests are linked to weight\u2010for\u2010height and height\u2010for\u2010age, suggesting liver disease as a contributing factor in the growth of children with biliary atresia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70735","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:06:04Z","timestamp":1788599164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth and Fibrosis in Children With Biliary Atresia: A Retrospective Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0649-8684","authenticated-orcid":false,"given":"Cecilie","family":"Lindebjerg","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Bo","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-9603","authenticated-orcid":false,"given":"Lars S\u00f8ndergaard","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-8839","authenticated-orcid":false,"given":"Thora Wesenberg","family":"Helt","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-3832","authenticated-orcid":false,"given":"Vibeke Brix","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Gynaecology, Fertility and Obstetrics Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Paediatric Surgery Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"issue":"9702","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary Atresia","volume":"374","author":"Hartley J. L.","year":"2009","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"132089","article-title":"Biliary Atresia: 50\u2009Years After the First Kasai","volume":"2012","author":"Wildhaber B. E.","year":"2012","journal-title":"International Scholarly Research Notices"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/978-3-642-54053-0_10","volume-title":"Pathology of Pediatric Gastrointestinal and Liver Disease","author":"Russo P.","year":"2014"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/lt.26339","article-title":"Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes","volume":"28","author":"Boster J. M.","year":"2022","journal-title":"Liver Transplantation"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41390-025-03939-9","article-title":"Early Life Growth Is Related to Pubertal Growth and Adult Height\u2014A QEPS\u2010Model Analysis","volume":"98","author":"Skogastierna C.","year":"2025","journal-title":"Pediatric Research"},{"issue":"2","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/MPG.0b013e3181623279","article-title":"Growth and Final Height After Liver Transplantation During Childhood","volume":"47","author":"Scheenstra R.","year":"2008","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"3","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/00007890-199902150-00011","article-title":"Factors Affecting Growth After Pediatric Liver Transplantation","volume":"67","author":"McDiarmid S. 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H.","year":"1987","journal-title":"American Journal of Diseases of Children"},{"issue":"2","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/apa.12468","article-title":"The 2014 Danish References From Birth to 20\u2009Years for Height, Weight and Body Mass Index","volume":"103","author":"Tinggaard J.","year":"2014","journal-title":"Acta Paediatrica"},{"issue":"2","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A Simple Noninvasive Index Can Predict Both Significant Fibrosis and Cirrhosis in Patients With Chronic Hepatitis C","volume":"38","author":"Wai C.\u2010T.","year":"2003","journal-title":"Hepatology"},{"issue":"6","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a Simple Noninvasive Index to Predict Significant Fibrosis in Patients With HIV\/HCV Coinfection","volume":"43","author":"Sterling R. 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V.","year":"2002","journal-title":"Transplantation"},{"key":"e_1_2_11_14_1","unstructured":"\u201cRigshospitalet Labportal\u201d(2025) https:\/\/labportal.rh.dk\/Labportal.asp?ShowStart=Y."},{"issue":"2","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MPG.0000000000000986","article-title":"Liver Transplantation for Biliary Atresia: Is There a Difference in Outcome for Infants?","volume":"62","author":"Arnon R.","year":"2016","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"3","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1399-3046.2004.00160.x","article-title":"Evaluation of Catch\u2010Up Growth After Liver Transplantation in Children With Biliary Atresia","volume":"8","author":"Alonso G.","year":"2004","journal-title":"Pediatric Transplantation"},{"issue":"5","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0022-3476(99)70062-4","article-title":"Linear Growth After Pediatric Liver Transplantation","volume":"135","author":"Bartosh S. M.","year":"1999","journal-title":"Journal of Pediatrics"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"35","article-title":"Insulin\u2010Like Growth Factors I and II Are Reduced in Plasma From Growth Retarded Children With Chronic Liver Disease","volume":"4","author":"Quirk P.","year":"1994","journal-title":"Growth Regulation"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1007\/s10620-014-3494-7","article-title":"The Evaluation of Hepatic Fibrosis Scores in Children With Nonalcoholic Fatty Liver Disease","volume":"60","author":"Mansoor S.","year":"2015","journal-title":"Digestive Diseases and Sciences"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:06:06Z","timestamp":1788599166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":18,"alternative-id":["10.1111\/apa.70735"],"URL":"https:\/\/doi.org\/10.1111\/apa.70735","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]},"assertion":[{"value":"2026-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"apa.70735"}}