{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:20Z","timestamp":1788347660377,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21AI169309"],"award-info":[{"award-number":["1R21AI169309"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020366","name":"Massachusetts Consortium on Pathogen Readiness","doi-asserted-by":"publisher","award":["GRT65691"],"award-info":[{"award-number":["GRT65691"]}],"id":[{"id":"10.13039\/100020366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","award":["GRT66673"],"award-info":[{"award-number":["GRT66673"]}],"id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether remote recruitment, electronic consent and at\u2010home blood collection enabled enrollment of a geographically and socioeconomically diverse infant cohort in the United States (US).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe the demographics of 256 infants included in this analysis, drawn from 264 enrolled in the Infant Vaccine Biorepository (December 2022\u2013April 2026). Participants were recruited via online advertising and electronic medical record messaging. Geographic distribution was assessed using US Census regions and Rural\u2013Urban Commuting Area (RUCA) codes. Social vulnerability was characterized using the Centers for Disease Control and Prevention (CDC) Social Vulnerability Index (SVI) at census tract and county levels, with nationwide rankings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infants were distributed evenly across the four US geographic regions; 9% resided in rural areas. Based on nationwide census tract\u2010level SVI rankings, 39.8% of participants fell in the medium\u2010high or high vulnerability categories. County\u2010level SVI rankings indicated that 57.0% of participants fell in these same categories. Participants were 78% White and 20% Hispanic; 94.1% of mothers had received at least one COVID\u201019 vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fully remote recruitment, consent and specimen collection enabled enrollment of infants from diverse geographic and socioeconomic backgrounds across the US. SVI and RUCA provide richer characterization of study populations than traditional demographic measures alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70750","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:27:15Z","timestamp":1788344835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remote Recruitment to Diversify Infant Research Participation: Lessons From the Infant Vaccine Biepository"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3134-9404","authenticated-orcid":false,"given":"Eleanor","family":"Nicholson","sequence":"first","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5713-6127","authenticated-orcid":false,"given":"Ritobhas","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Stonestreet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganad","family":"Neka","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7850-9531","authenticated-orcid":false,"given":"Audrey","family":"Mutoni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7934-4286","authenticated-orcid":false,"given":"Amanda","family":"Michael","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-0689","authenticated-orcid":false,"given":"Tina Yi Jin","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4668-4671","authenticated-orcid":false,"given":"McKenzi","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6442-2581","authenticated-orcid":false,"given":"Valerie","family":"Perrinez","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Barrero\u2010Castillero","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Neonatology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-3960","authenticated-orcid":false,"given":"Ai\u2010ris Y.","family":"Collier","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.37640"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2023.104135"},{"key":"e_1_2_14_4_1","volume-title":"Drug Trials Snapshots Summary Report 2024","author":"Center for Drug Evaluation and Research","year":"2024"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.11516"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","unstructured":"M.Aziz E. 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