{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:59:05Z","timestamp":1790413145099,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We assessed the prevalence of atopic comorbidities and healthcare service use among children with food allergies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective matched cohort study used data from a large health maintenance organisation, which insures and provides universal healthcare services. Children aged 0\u201318\u2009years who were diagnosed with food allergies from 2001 to 2019 were matched 1:1 with non\u2010allergic controls. Data on demographics, rate of comorbidities, and healthcare use were compared. Adjusted odds ratios (aOR) and confidence intervals (CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 20\u2009418 children with food allergies and matched them to 20\u2009418 controls. Cases had significantly higher rates of allergic comorbidities, including allergic rhinitis (aOR 2.09, 95% CI 1.95\u20132.25), atopic dermatitis (aOR 2.04, 95% CI 1.94\u20132.14), and eosinophilic esophagitis (aOR 15.4, 95% CI 6.04\u201339.55; 104 vs. 5 events). Most prescription rates were markedly elevated, particularly for hydrolysed formulas (aOR 12.32, 95% CI 10.83\u201314.0). Specialist consultations were more frequent, with the greatest increases in gastroenterology (aOR 2.23, 95% CI 2.09\u20132.37) and pulmonology (aOR 2.03, 95% CI 1.90\u20132.17). General healthcare use was higher, including emergency department visits and hospitalisations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paediatric food allergies were associated with a substantially higher burden of atopic comorbidities and increased healthcare use in this large national cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70764","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:31:33Z","timestamp":1790411493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Food Allergies Are Associated With a Substantially Higher Burden of Atopic Comorbidities and Increased Healthcare Use"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2196-8327","authenticated-orcid":false,"given":"Anna Berezin","family":"Shoham","sequence":"first","affiliation":[{"name":"Medical Division Maccabi Healthcare Services  Tel Aviv Israel"},{"name":"Department of Pediatrics Shamir Medical Center  Zerifin Israel"},{"name":"The Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital Perlov","family":"Gavze","sequence":"additional","affiliation":[{"name":"Medical Division Maccabi Healthcare Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Lev\u2010Shalem","sequence":"additional","affiliation":[{"name":"Medical Division Maccabi Healthcare Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-8143","authenticated-orcid":false,"given":"Arnon","family":"Elizur","sequence":"additional","affiliation":[{"name":"The Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir Medical Center  Zerifin Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7626","authenticated-orcid":false,"given":"Amir Ben","family":"Tov","sequence":"additional","affiliation":[{"name":"Medical Division Maccabi Healthcare Services  Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-1782","authenticated-orcid":false,"given":"Naama","family":"Epstein\u2010Rigbi","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Unit Assuta Ashdod Medical Center  Ashdod Israel"},{"name":"Faculty of Health Science Ben Gurion University  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13362"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.029"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.anai.2019.12.021","article-title":"Quality of Life in Food Allergic Children: Results From 174 Quality\u2010Of\u2010Life Patient Questionnaires","volume":"124","author":"Miller J.","year":"2020","journal-title":"Annals of Allergy, Asthma & Immunology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.jaip.2024.03.015","article-title":"The Prevalence of IgE\u2010Mediated Food Allergy and Other Allergic Diseases in the First 10\u2009Years: The Population\u2010Based, Longitudinal HealthNuts Study","volume":"12","author":"Peters R. 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