{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:53:19Z","timestamp":1791031999948,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the incidence of culture\u2010proven sepsis and examine the correlation between positive blood cultures and nurse staffing in a Level IV neonatal intensive care unit (NICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included neonates with \u2265\u20091 positive blood culture and signs of infection between 2018 and 2023. Infection episodes were defined as culture\u2010proven sepsis treated with antibiotics for \u2265\u20093\u2009days and divided into early\u2010onset sepsis (EOS), \u2264\u200972\u2009h after birth or late\u2010onset sepsis (LOS), &gt;\u200972\u2009h after birth. Nurse staffing was prospectively recorded and expressed as the ratio of actual to recommended attendance according to British Association of Perinatal Medicine standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 6 856 admissions, 514 episodes of positive blood cultures were identified in 310 neonates; 421 (82%) were classified as infections. Coagulase\u2010negative staphylococci were the predominant pathogen. The incidence of positive blood cultures increased from 5.4% in 2018\u20132020 to 6.9% in 2021\u20132023. EOS increased (from 0.6% to 1.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). There was an inverse correlation between nurse staffing levels and number of LOS episodes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Culture\u2010proven sepsis increased over time in this NICU, primarily driven by EOS. Higher numbers of LOS episodes correlated with lower nurse staffing levels, suggesting a potential role of adequate staffing in infection prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70783","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:43:30Z","timestamp":1791024210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Culture\u2010Proven Neonatal Sepsis and Its Correlation With Nurse Staffing in a Level\n                    <scp>IV<\/scp>\n                    Neonatal Intensive Care Unit: A Six\u2010Year Cohort Study"],"prefix":"10.1111","author":[{"given":"A.","family":"Gudiksen","sequence":"first","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-4822","authenticated-orcid":false,"given":"M.","family":"Breindahl","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-4616","authenticated-orcid":false,"given":"F. B.","family":"Hertz","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Immunology and Microbiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Immunology and Microbiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-6167","authenticated-orcid":false,"given":"S. A.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3666-7581","authenticated-orcid":false,"given":"S. G.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-429X","authenticated-orcid":false,"given":"L.","family":"Aunsholt","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-1964","authenticated-orcid":false,"given":"E. M.","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Pediatric Intensive Care Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31002\u20104"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00495\u20101"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20102013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43691"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2024.29.3.2300193"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2025.101665"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.23\u201010\u2010e738"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102022\u2010324977"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1373"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102022\u2010324414"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16494"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(16)30082\u20102"},{"key":"e_1_2_12_14_1","unstructured":"British Association of Perinatal Medicine \u201cCategories of Care \u201dhttps:\/\/www.bapm.org\/resources\/34\u2010categories\u2010of\u2010care\u20102011."},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad358"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.70103"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.0593"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010024\u201004809\u20108"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2024.10.003"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002976"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1128"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010019\u20103981\u20108"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072621"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.1.F25"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(96)70254\u20108"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70783","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:10:47Z","timestamp":1791029447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":24,"alternative-id":["10.1111\/apa.70783"],"URL":"https:\/\/doi.org\/10.1111\/apa.70783","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"apa.70783"}}