{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:42:06Z","timestamp":1792590126915,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Perinatal stroke can cause lifelong morbidities. Outcome prediction is important for parental guidance and follow\u2010up. We studied characteristics of acute perinatal stroke in a Finnish cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a population\u2010based study, identifying infants with acute neonatal cerebral ischemia or sinovenous thrombosis (CSVT) in Southern Finland from 2010 to 2023. We analysed the incidence of stroke types, seizures, anti\u2010seizure medication use, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether 88 infants (1 in 3101 live births) were diagnosed with acute perinatal stroke: 67% with arterial ischemic stroke (AIS), 22% with hemorrhagic stroke (HS) and 11% with CSVT. Seizures and anti\u2010seizure medication use occurred in 78% of infants. Cranial ultrasound infrequently recognized AIS but usually noted haemorrhage. During follow\u2010up, 34% of infants had no adverse outcome diagnosis. The most common outcome was cerebral palsy (CP, 35%). A combination of CP with epilepsy or seizures was more frequent in infants with AIS than in those with other stroke types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The distribution of stroke types, symptoms, and adverse outcomes aligns with the previous literature. Acute seizures were common in AIS and HS patients. No recurrent strokes occurred during follow\u2010up and underlying infant\u2010related etiologies were rarely identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70797","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:00:42Z","timestamp":1792587642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Perinatal Stroke Characteristics and Outcome in Southern Finland"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-1849","authenticated-orcid":false,"given":"Maija","family":"Sepp\u00e4\u2010Moilanen","sequence":"first","affiliation":[{"name":"Department of Child Neurology, New Children's Hospital University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Pediatric Research Center University of Helsinki and Helsinki University Hospital|  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siina","family":"Pamilo","sequence":"additional","affiliation":[{"name":"New Children's Hospital Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Leinonen","sequence":"additional","affiliation":[{"name":"Bayer Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Mets\u00e4ranta","sequence":"additional","affiliation":[{"name":"Pediatric Research Center University of Helsinki and Helsinki University Hospital|  Helsinki Finland"},{"name":"Department of Pediatrics New Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuli","family":"Rautava","sequence":"additional","affiliation":[{"name":"Pediatric Research Center University of Helsinki and Helsinki University Hospital|  Helsinki Finland"},{"name":"Department of Pediatrics New Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-1614","authenticated-orcid":false,"given":"Pirjo","family":"Isohanni","sequence":"additional","affiliation":[{"name":"Department of Child Neurology, New Children's Hospital University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Pediatric Research Center University of Helsinki and Helsinki University Hospital|  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-5811","authenticated-orcid":false,"given":"Miika","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Pediatric Research Center University of Helsinki and Helsinki University Hospital|  Helsinki Finland"},{"name":"Department of Pediatrics New Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Diagnostic Center University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1542\/peds.2007-0336","article-title":"Ischemic Perinatal Stroke: Summary of a Workshop Sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke","volume":"120","author":"Raju T. 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