{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:06:18Z","timestamp":1792796778004,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This review aims to provide researchers and clinicians involved with the adult lower urinary tract with background knowledge regarding the early development of bladder function and its most common disturbances in childhood. Bladder development begins in weeks 4\u20136 and the detrusor muscle is formed during weeks 9\u201312 of gestation. Higher\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    centres are involved in micturition at birth, and the infant usually wakes up, at least briefly, to void. Voiding during the first years of life is often incomplete, owing to detrusor\u2010sphincter dyscoordination, but this disappears when bladder control is attained. Approximately 5\u201310% of 7\u2010year\u2010old children suffer from daytime incontinence and\/or nocturnal enuresis, and a few per cent of them will not outgrow it. Daytime incontinence in childhood is usually attributable to detrusor overactivity, although it is unclear to what extent it is the detrusor or the micturition reflex\n                    <jats:italic>per se<\/jats:italic>\n                    that is overactive. Enuresis \u2013 nocturnal incontinence \u2013 is caused by either nocturnal polyuria and\/or nocturnal detrusor overactivity, in both cases combined with high arousal thresholds. Bladder problems in childhood constitute a risk factor for the development or persistence of bladder problems in adulthood.\n                  <\/jats:p>","DOI":"10.1111\/apha.12015","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T09:16:21Z","timestamp":1350897381000},"page":"85-92","source":"Crossref","is-referenced-by-count":55,"title":["Lower urinary tract function in childhood; normal development and common functional disturbances"],"prefix":"10.1111","volume":"207","author":[{"given":"T.","family":"Nev\u00e9us","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Sill\u00e9n","sequence":"additional","affiliation":[{"name":"Paediatric Urology Unit Queen Silvia's Children's Hospital G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00583-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68226-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.5.573"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655902320783863"},{"key":"e_1_2_10_6_1","first-page":"5","article-title":"Bladder dysfunction in children","volume":"2","author":"Cisternino A.","year":"1995","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_10_7_1","first-page":"855","article-title":"Evidence for the locus coeruleus involvement in desipramine action in animal models of depression","volume":"37","author":"Danysz W.","year":"1985","journal-title":"Pol J Pharmacol Pharm"},{"key":"e_1_2_10_8_1","first-page":"118","article-title":"Prevalence and risk factors for childhood nocturnal enuresis","volume":"84","author":"Devlin J.B.","year":"1991","journal-title":"Ir Med J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091219.46560.7b"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.11.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08576.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655901753224396"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000135617.02742.ad"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.040"},{"key":"e_1_2_10_15_1","first-page":"79","article-title":"Self\u2010esteem before and after treatment in children with nocturnal enuresis and urinary incontinence","volume":"31","author":"H\u00e4ggl\u00f6f B.","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02009667"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599709030657"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65543-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62596-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902500404"},{"key":"e_1_2_10_21_1","first-page":"77","article-title":"Polyuric and non\u2010polyuric bedwetting \u2013 pathogenetic differences in nocturnal enuresis","volume":"173","author":"Hunsballe J.M.","year":"1995","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66963-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000161216.45653.e3"},{"key":"e_1_2_10_24_1","first-page":"1","article-title":"Brain stem mechanisms of sleep and wakefulness","volume":"55","author":"Kayama Y.","year":"1993","journal-title":"J Physiol Soc Jpn"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.08.026"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.53.8.453"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240508"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.2.228"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00086.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00283.2011"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb00775.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1016"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.21-18-j0002.2001","article-title":"Loss of purinergic P2X3 and P2X5 receptor innervation in human detrusor from adults with urge incontinence","volume":"21","author":"Moore K.H.","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0390-1"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66285-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00305-3"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.036"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00205-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.040"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90169-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599609182350"},{"key":"e_1_2_10_42_1","first-page":"F664","article-title":"Abnormal diurnal rhythm of plasma Vasopressin and urinary output in patients with enuresis","volume":"256","author":"Rittig S.","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008880410015219"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68036-6"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02966.x"},{"key":"e_1_2_10_46_1","first-page":"174","article-title":"Socio\u2010medical study of enuresis among delinquent boys","volume":"19","author":"Stein Z.","year":"1965","journal-title":"Br J Prev Soc Med"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00641.2002"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500314"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb09027.x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07682.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68062-5"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06074.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132769.71014.b5"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:40:39Z","timestamp":1698666039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,22]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/apha.12015"],"URL":"https:\/\/doi.org\/10.1111\/apha.12015","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,22]]}}}