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The efficiency of the lung\u2013chest wall coupling depends upon pleural liquid volume, which in turn reflects the balance between the filtration of fluid into and its egress out of the cavity. While filtration occurs through a single mechanism passively driving fluid from the interstitium of the parietal pleura into the cavity, several mechanisms may co\u2010operate to remove pleural fluid. Among these, the pleural lymphatic system emerges as the most important one in quantitative terms and the only one able to cope with variable pleural fluid volume and drainage requirements. In this review, we present a detailed account of the actual knowledge on: (a) the complex morphology of the pleural lymphatic system, (b) the mechanism supporting pleural lymph formation and propulsion, (c) the dependence of pleural lymphatic function upon local tissue mechanics and (d) the effect of lymphatic inefficiency in the development of clinically severe pleural and, more in general, respiratory pathologies.<\/jats:p>","DOI":"10.1111\/apha.12016","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T16:53:05Z","timestamp":1348678385000},"page":"244-259","source":"Crossref","is-referenced-by-count":44,"title":["Pleural function and lymphatics"],"prefix":"10.1111","volume":"207","author":[{"given":"D.","family":"Negrini","sequence":"first","affiliation":[{"name":"Department of Surgical and Morphological Sciences University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moriondo","sequence":"additional","affiliation":[{"name":"Department of Surgical and Morphological Sciences University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1972.52.1.57"},{"key":"e_1_2_11_3_1","first-page":"531","volume-title":"Handbook of Physiology. 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