{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:04:06Z","timestamp":1761581046884},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T00:00:00Z","timestamp":1358467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine whether dynamic characteristics of the peripheral vagal control of heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) are altered in chronic heart failure (<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The right vagal nerve was electrically stimulated according to a binary white noise signal, and the transfer function from vagal nerve stimulation (<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>) to <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was estimated in the frequency range from 0.01 to 1\u00a0Hz in five control rats and five <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> rats under anaesthetized conditions. The rate of <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> was changed among 10, 20 and 40\u00a0Hz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A multiple linear regression analysis indicated that the increase in the <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> rate augmented the ratio of the high\u2010frequency (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) gain to the steady\u2010state gain in the control group but not in the <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> group. As a result, the dynamic gain of the transfer function in the frequencies near 1\u00a0Hz decreased more in the <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> group than in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in the dynamic characteristics of the peripheral vagal control of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> may contribute to the manifestation of decreased <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> components of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> variability observed in <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12055","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T23:26:08Z","timestamp":1356132368000},"page":"494-502","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure"],"prefix":"10.1111","volume":"207","author":[{"given":"T.","family":"Kawada","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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