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The calcium channel family consists of several subfamilies, of which the<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010type is usually associated with vascular contractility. However, the<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010,<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>\u2010types of calcium channels are present in the renal vasculature and are differentially involved in controlling vascular contractility, thereby contributing to regulation of kidney function and blood pressure. In the preglomerular vascular bed, all the three channel families are present. However, the<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010type channel is the only channel in cortical efferent arterioles which is in contrast to the juxtamedullary efferent arteriole, and that leads to diverse functional effects of<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010type channel inhibition. Furthermore, by different mechanisms,<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010type channels may contribute to both constriction and dilation of the arterioles. Finally,<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>\u2010type channels are involved in the regulation of human intrarenal arterial contractility. The calcium blockers used in the clinic affect not only<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010type but also<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010\/<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010type channels. Therefore, the distinct effect obtained by inhibiting a given subtype or set of channels under experimental settings should be considered when choosing a calcium blocker for treatment. T\u2010type channels seem to be crucial for regulating the GFR and the filtration fraction. Use of blockers is expected to lead to preferential efferent vasodilation, reduction of glomerular pressure and proteinuria. Therefore, renovascular T\u2010type channels might provide novel therapeutic targets, and may have superior renoprotective effects compared to conventional calcium blockers.<\/jats:p>","DOI":"10.1111\/apha.12070","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T04:56:48Z","timestamp":1359349008000},"page":"690-699","source":"Crossref","is-referenced-by-count":30,"title":["Functional and pharmacological consequences of the distribution of voltage\u2010gated calcium channels inthe renal blood vessels"],"prefix":"10.1111","volume":"207","author":[{"given":"P. B. 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