{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T06:41:22Z","timestamp":1727073682249},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological studies related poor maternal nutrition and subsequent growth retardation in the progeny to the development of diabetes later in life. Low\u2010protein diet during gestation altered the beta\u2010cell development of the rat progeny by decreasing beta\u2010cell proliferation and increasing their sensitivity to nitric oxide and cytokines in the foetus. This disturbed maternal environment had long\u2010lasting consequences because the higher beta\u2010cell vulnerability was maintained at adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine whether early malnutrition influences the vulnerability and the regeneration capacity of beta\u2010cells after streptozotocin (<jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>) damage at adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gestating rats were fed either a control or a low\u2010protein diet until weaning. Adult female offspring received injections of Freund's adjuvant weekly for 5\u00a0weeks followed 24\u00a0h later by <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>. Half of the cohort was killed at d34, whereas the other half was maintained until d48 to analyse the regeneration capacity of the beta\u2010cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although control and low\u2010protein rats had equivalent pancreatic insulin content and beta\u2010cell volume density at d34, hyperglycaemia appeared earlier and was more dramatic in low\u2010protein rats than in control rats. <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content> treatment increased beta\u2010cell proliferation similarly in both groups. At d48, apoptotic rate was higher in the low\u2010protein group. Regeneration appeared in control, but not in the low\u2010protein rats, where beta\u2010cell aggregates\/surface area and Reg1\u2010positive area were decreased compared to control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal malnutrition programmes a more vulnerable endocrine pancreas in the progeny which is unable to regenerate after injury, therefore predisposing it to develop glucose intolerance and diabetes later in life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12121","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T17:18:22Z","timestamp":1369329502000},"page":"99-109","source":"Crossref","is-referenced-by-count":5,"title":["Increased susceptibility to streptozotocin and impeded regeneration capacity of beta\u2010cells in adult offspring of malnourished rats"],"prefix":"10.1111","volume":"210","author":[{"given":"K.","family":"Goosse","sequence":"first","affiliation":[{"name":"Laboratory of Cell 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