{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:37:33Z","timestamp":1788518253044,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of a nutritional mixture (bovine milk oligosaccharides, <jats:italic>Lactobacillus rhamnosus <\/jats:italic><jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>4007, arachidonic and docosahexaenoic acid) on growth of intrauterine growth\u2010restricted (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> was induced by maternal food restriction. The offspring (males and females) were assigned to: REF (non\u2010<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, no mixture), <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>c (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, no mixture), or <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>mx (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, mixture). The mixture was given from day 7 to day 58, when tissues and plasma from half of the animals were collected for hormones, metabolites and microarray analysis. The rest received a high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) until day 100. Glucose tolerance was measured at 56 and 98\u00a0days, and body fat content at 21, 52 and 97\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IUGRmx had the greatest growth during lactation, but from day 22 to day 54, both IUGR groups gained less body weight than the REF (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In the short\u2010term (58\u00a0days), IUGRmx tended to be longer (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and had less body fat (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) than IUGRc. These differences were not seen after HFD. Microarray analysis of hepatic <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression at 58 and 100\u00a0days revealed a gender\u2010dependent treatment effect, and expression of genes related to lipid metabolism was the most affected. Twelve of these genes were selected for studying differences in DNA methylation in the promoter region, for some, we observed age\u2010 and gender\u2010related differences but none because of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The nutritional intervention promoted catch\u2010up growth and normalized excessive adiposity in <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> animals at short\u2010term. The benefits did not extend after a period of <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and early diet had gender\u2010dependent effects on hepatic gene expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12145","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T16:12:08Z","timestamp":1373299928000},"page":"161-173","source":"Crossref","is-referenced-by-count":11,"title":["Effect of a mixture of bovine milk oligosaccharides, <i><scp>L<\/scp>actobacillus rhamnosus <\/i><scp>NCC<\/scp>4007 and long\u2010chain polyunsaturated fatty acids on catch\u2010up growth of intra\u2010uterine growth\u2010restricted rats"],"prefix":"10.1111","volume":"210","author":[{"given":"E.","family":"Casta\u00f1eda\u2010Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health Nestl\u00e9 Research Center  Lausanne 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