{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:03:15Z","timestamp":1779310995883,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Excess weight gain and obesity are one of the most serious health problems in the western societies. These conditions enhance risk of cardiac disease and have been linked with increased prevalence for cardiac arrhythmias and sudden death. Our goal was to study the ventricular remodelling occurring in rabbits fed with high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) and its potential arrhythmogenic mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used 15 <jats:styled-content style=\"fixed-case\">NZW<\/jats:styled-content> rabbits that were randomly assigned to a control (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) or <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> group (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) for 18\u00a0weeks. <jats:italic>In vivo<\/jats:italic> studies included blood glucose, electrocardiographic, and echocardiographic measurements. Optical mapping was performed in Langendorff\u2010perfused isolated hearts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight (3.69\u00a0\u00b1\u00a00.31 vs. 2.94\u00a0\u00b1\u00a00.18\u00a0kg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and blood glucose levels (230\u00a0\u00b1\u00a061 vs. 141\u00a0\u00b1\u00a014\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) were higher in the HFD group vs. controls. The rate\u2010corrected QT interval and its dispersion were increased in HFD rabbits vs. controls (169\u00a0\u00b1\u00a010 vs. 146\u00a0\u00b1\u00a013\u00a0ms and 37\u00a0\u00b1\u00a011 vs. 9\u00a0\u00b1\u00a02\u00a0ms, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Echocardiographic analysis showed morphological and functional alterations in HFD rabbits indicative of left ventricle (LV) hypertrophy. Isolated heart studies revealed no changes in repolarization and propagation properties under conditions of normal extracellular K<jats:sup>+<\/jats:sup>, suggesting that extrinsic factors could underlie those electrocardiographic modifications. There were no differences in the dynamics of ventricular fibrillation (frequency, wave breaks) in the presence of isoproterenol. However, HFD rabbits showed a small reduction in action potential duration and an increased incidence of arrhythmias during hyperkalaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010fat feeding during 18\u00a0weeks in rabbits induced a type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> diabetes phenotype, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> hypertrophy, abnormalities in repolarization and susceptibility to arrhythmias during hyperkalaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12185","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T13:26:58Z","timestamp":1382707618000},"page":"36-47","source":"Crossref","is-referenced-by-count":26,"title":["Ventricular remodelling in rabbits with sustained high\u2010fat diet"],"prefix":"10.1111","volume":"211","author":[{"given":"M.","family":"Zarzoso","sequence":"first","affiliation":[{"name":"Center for Arrhythmia Research University of Michigan Ann Arbor MI USA"},{"name":"Department of Physiotherapy Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mironov","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Guerrero\u2010Serna","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Cicero","family":"Willis","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. V.","family":"Pandit","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2012.02441.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.11.015"},{"key":"e_1_2_7_5_1","first-page":"H373","article-title":"Hypertension, cardiac hypertrophy, and neurohumoral activity in a new animal model of obesity","volume":"271","author":"Carroll J.F.","year":"1996","journal-title":"Am J 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