{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:58:06Z","timestamp":1782885486873,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Gastroparesis is a common non\u2010motor system symptom of Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). However, the mechanism responsible for the gastric motor abnormality is not clear. We previously reported on the impaired gastric motility in 6\u2010hydroxydopamine (6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>) rats, which were treated with a bilateral microinjection of 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> in the substantia nigra (<jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>). We hypothesize that the enhanced dopamine system and reduced acetylcholine (Ach) in gastric tissues might contribute to the delayed gastric emptying observed in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A strain gauge force transducer, digital <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray imaging system, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern blot, immunofluorescence and Radio Immunoassay were used in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dopaminergic neurones in the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> were greatly reduced following the bilateral microinjection of 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>. 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> rats exhibited impaired gastric motility and delayed gastric emptying, accompanied by increased dopamine content and the overexpression of D<jats:sub>2<\/jats:sub> receptors in the stomach. The administration of the D<jats:sub>2<\/jats:sub> receptor antagonist domperidone relieved gastric dysmotility in 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> rats, but the D<jats:sub>1<\/jats:sub> receptor antagonist <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>23390 failed to do so. Subdiaphragmatic vagotomy prevented the increase in the gastric dopamine content and D<jats:sub>2<\/jats:sub> receptor expression and improved gastric dysmotility in 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dopaminergic deficiency in the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> results in impaired gastric motility, possibly as a result of the enhanced activity of dopamine system and reduced Ach in gastric tissue. The vagus nerve plays an important role in peripheral gastric motility disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12229","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T18:55:32Z","timestamp":1389466532000},"page":"434-446","source":"Crossref","is-referenced-by-count":74,"title":["The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6\u2010hydroxydopamine microinjection in the substantia nigra"],"prefix":"10.1111","volume":"211","author":[{"given":"L.\u2010F.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Capital Medical University Beijing 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