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In megakaryocytes,\n                    <jats:styled-content style=\"fixed-case\">SGK<\/jats:styled-content>\n                    1 activates transcription factor nuclear factor kappa\u2010B (\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B), which in turn stimulates expression of Orai1, a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel protein accomplishing store\u2010operated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    enrty (\n                    <jats:styled-content style=\"fixed-case\">SOCE<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">SGK<\/jats:styled-content>\n                    1 enhances\n                    <jats:styled-content style=\"fixed-case\">SOCE<\/jats:styled-content>\n                    and several Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010sensitive platelet functions, including degranulation, integrin\n                    <jats:italic>\u03b1<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:sub>II<\/jats:sub>\n                    <\/jats:styled-content>\n                    <jats:sub>b<\/jats:sub>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    activation, phosphatidylserine exposure, aggregation and thrombus formation. As shown in other cell types, stimulators of\n                    <jats:styled-content style=\"fixed-case\">SGK<\/jats:styled-content>\n                    1 expression include ischaemia, oxidative stress, hyperglycaemia, advanced glycation end products (\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s) and a variety of hormones such as glucocorticoids, mineralocorticoids, transforming growth factor beta (\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ), interleukin 6 (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106), platelet\u2010derived growth factor (\n                    <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\n                    ), thrombin and endothelin. Thus,\n                    <jats:styled-content style=\"fixed-case\">SGK<\/jats:styled-content>\n                    1\u2010sensitive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signalling may contribute to altered platelet function in several clinical conditions including inflammation, metabolic syndrome, diabetes mellitus and chronic renal failure. Nevertheless, further studies are needed defining the contribution of altered\n                    <jats:styled-content style=\"fixed-case\">SGK<\/jats:styled-content>\n                    1 expression and activity to physiology and pathophysiology of platelets.\n                  <\/jats:p>","DOI":"10.1111\/apha.12334","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T12:59:11Z","timestamp":1403182751000},"page":"181-190","source":"Crossref","is-referenced-by-count":20,"title":["The serum\u2010 &amp; glucocorticoid\u2010inducible kinase in the regulation of platelet function"],"prefix":"10.1111","volume":"213","author":[{"given":"F.","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Physiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology &amp; Cardiovascular 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