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Peripheral 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    is predominantly produced by enterochromaffin (\n                    <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\n                    ) cells of the gastrointestinal (\n                    <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                    ) tract. These gut\u2010resident cells produce much more 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    than all neuronal and other sources combined, establishing\n                    <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\n                    cells as the main source of this biogenic amine in the human body. Peripheral 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    is also a potent immune modulator and affects various immune cells through its receptors and via the recently identified process of serotonylation. Alterations in 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    signalling have been described in inflammatory conditions of the gut, such as inflammatory bowel disease. The association between 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    and inflammation, however, is not limited to the gut, as changes in 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    levels have also been reported in patients with allergic airway inflammation and rheumatoid arthritis. Based on searches for terms such as \u20185\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    \u2019, \u2018\n                    <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\n                    cell\u2019, \u2018immune cells\u2019 and \u2018inflammation\u2019 in pubmed.gov as well as by utilizing pertinent reviews, the current review aims to provide an update on the role of 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    in biological functions with a particular focus on immune activation and inflammation.\n                  <\/jats:p>","DOI":"10.1111\/apha.12430","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T00:01:36Z","timestamp":1417219296000},"page":"561-574","source":"Crossref","is-referenced-by-count":345,"title":["The role of serotonin and its receptors in activation of immune responses and inflammation"],"prefix":"10.1111","volume":"213","author":[{"given":"M. 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