{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:45:48Z","timestamp":1785314748833,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Visceral adipose tissue\u2010derived serine protease inhibitor (vaspin) is a relatively novel adipocytokine with protective effects on metabolic diseases including obesity and type II diabetes. We have previously demonstrated that vaspin exerts anti\u2010inflammatory and antimigratory roles through antioxidative effects in vascular smooth muscle cells. As inflammatory responses and migration of smooth muscle in peripheral vascular wall are key mechanisms for the pathogenesis of hypertension, we hypothesized that vaspin could prevent the development of hypertension in <jats:italic>in\u00a0vivo<\/jats:italic> hypertensive animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vaspin (1\u00a0<jats:italic>\u03bc<\/jats:italic>g\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) was administered intraperitoneally to 5\u2010week\u2010old male spontaneously hypertensive rats (<jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>) for 4\u00a0weeks. Superior mesenteric artery was isolated and used for measurement of isometric contraction and histological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Long\u2010term vaspin treatment significantly prevented an elevation of systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) at 8\u00a0weeks of age. Vaspin had no effect on reactivity of isolated mesenteric artery from <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>. In contrast, vaspin significantly inhibited mesenteric arterial wall hypertrophy in <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>. Moreover, vaspin significantly inhibited an increase of tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> expression and a production of reactive oxygen species in isolated mesenteric artery from SHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study for the first time demonstrates that vaspin prevents the increase of <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> through inhibiting peripheral vascular hypertrophy possibly via antioxidative and anti\u2010inflammatory mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12636","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T17:58:49Z","timestamp":1449597529000},"page":"120-129","source":"Crossref","is-referenced-by-count":24,"title":["Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodelling in spontaneously hypertensive rats"],"prefix":"10.1111","volume":"217","author":[{"given":"S.","family":"Kameshima","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pharmacology School of Veterinary Medicine Kitasato University Towada Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology School of Veterinary Medicine Kitasato University Towada Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Okada","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology School of Veterinary Medicine Kitasato University Towada Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology School of Veterinary Medicine Kitasato University Towada Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2015.00024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.08.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.07.026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000026820.87824.6A"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1258-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.38.5.362"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504703102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/jn\/118.1.114","article-title":"Mineral balance and blood pressure in the young spontaneously hypertensive rat","volume":"118","author":"Jones M.R.","year":"1988","journal-title":"J Nutr"},{"key":"e_1_2_7_10_1","article-title":"Visceral adipose tissue\u2010derived serine protease inhibitor augments acetylcholine\u2010induced relaxation via the inhibition of acetylcholine esterase activity in rat isolated mesenteric artery","author":"Kameshima S.","year":"2015","journal-title":"Acta Physiol (Oxf)"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00864.2014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0427-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5607"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.5.6.881"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00820.2014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs135"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00758.2002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.142646"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.02.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300049"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.03.025"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.06.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.052"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12139"},{"key":"e_1_2_7_25_1","first-page":"E658","article-title":"Insulin sensitivity and hemodynamic responses to insulin in Wistar\u2010Kyoto and spontaneously hypertensive rats","volume":"271","author":"Pitre M.","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ajh\/4.1.34","article-title":"Relationship between blood pressure, plasma insulin and triglyceride concentration, and insulin action in spontaneous hypertensive and Wistar\u2010Kyoto rats","volume":"4","author":"Reaven G.M.","year":"1991","journal-title":"Am J Hypertens"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121880"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2008.50"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000100443.09293.4F"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00033-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.200337"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00373.2013"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.45.2.250"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1425-5"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12636","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:59:53Z","timestamp":1696517993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,24]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/apha.12636"],"URL":"https:\/\/doi.org\/10.1111\/apha.12636","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,24]]}}}