{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:47:46Z","timestamp":1770781666018,"version":"3.50.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL-103673"],"award-info":[{"award-number":["HL-103673"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL-37981"],"award-info":[{"award-number":["HL-37981"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL-66233"],"award-info":[{"award-number":["HL-66233"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute of General Medicine","award":["GM-31278"],"award-info":[{"award-number":["GM-31278"]}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["GL625910"],"award-info":[{"award-number":["GL625910"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiol"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1111\/apha.12642","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T12:12:21Z","timestamp":1450181541000},"page":"188-201","source":"Crossref","is-referenced-by-count":19,"title":["Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries"],"prefix":"10.1111","volume":"219","author":[{"given":"L.","family":"Siangjong","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA"},{"name":"Faculty of Pharmacy; Silpakorn University; Nakorn Pathom Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kriska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; University of Pennsylvania; Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Puli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; University of Texas Southwestern Medical Center; Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; University of Texas Southwestern Medical Center; Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Falck","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; University of Texas Southwestern Medical Center; Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology; Medical College of Wisconsin; Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"10.1111\/apha.12642-BIB0001|apha12642-cit-0001","doi-asserted-by":"crossref","first-page":"23679","DOI":"10.1074\/jbc.274.34.23679","article-title":"Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate","volume":"274","author":"Brash","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/apha.12642-BIB0002|apha12642-cit-0002","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0090-6980(79)90071-6","article-title":"Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets","volume":"17","author":"Bryant","year":"1979","journal-title":"Prostaglandins"},{"key":"10.1111\/apha.12642-BIB0003|apha12642-cit-0003","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/01.HYP.0000255173.50317.fc","article-title":"Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors","volume":"49","author":"Campbell","year":"2007","journal-title":"Hypertension"},{"key":"10.1111\/apha.12642-BIB0004|apha12642-cit-0004","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/FJC.0b013e31828165db","article-title":"Inducible endothelium-derived hyperpolarizing factor: role of the 15-lipoxygenase-EDHF pathway","volume":"61","author":"Campbell","year":"2013","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1111\/apha.12642-BIB0005|apha12642-cit-0005","doi-asserted-by":"crossref","first-page":"H2648","DOI":"10.1152\/ajpheart.00412.2003","article-title":"11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta","volume":"285","author":"Campbell","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0006|apha12642-cit-0006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000209262","article-title":"TP receptor antagonism: a new concept in atherothrombosis and stroke prevention","volume":"27","author":"Chamorro","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1111\/apha.12642-BIB0007|apha12642-cit-0007","doi-asserted-by":"crossref","first-page":"H1348","DOI":"10.1152\/ajpheart.01326.2007","article-title":"Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta","volume":"294","author":"Chawengsub","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0008|apha12642-cit-0008","doi-asserted-by":"crossref","first-page":"H495","DOI":"10.1152\/ajpheart.00349.2009","article-title":"Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone","volume":"297","author":"Chawengsub","year":"2009a","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0009|apha12642-cit-0009","doi-asserted-by":"crossref","first-page":"31280","DOI":"10.1074\/jbc.M109.025627","article-title":"Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries","volume":"284","author":"Chawengsub","year":"2009b","journal-title":"J Biol Chem"},{"key":"10.1111\/apha.12642-BIB0010|apha12642-cit-0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jasms.2008.01.007","article-title":"Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR","volume":"19","author":"Cui","year":"2008","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1111\/apha.12642-BIB0011|apha12642-cit-0011","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1042\/bj2660063","article-title":"Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils","volume":"266","author":"Dho","year":"1990","journal-title":"Biochem J"},{"key":"10.1111\/apha.12642-BIB0012|apha12642-cit-0012","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.HYP.37.2.554","article-title":"Oxidative stress in a rat model of obesity-induced hypertension","volume":"37","author":"Dobrian","year":"2001","journal-title":"Hypertension"},{"key":"10.1111\/apha.12642-BIB0013|apha12642-cit-0013","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0022-3565(25)38141-3","article-title":"Thromboxane A2 stimulated signal transduction in vascular smooth muscle","volume":"265","author":"Dorn","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/apha.12642-BIB0014|apha12642-cit-0014","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/jmcc.1998.0840","article-title":"The alternative: EDHF","volume":"31","author":"Feletou","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1111\/apha.12642-BIB0015|apha12642-cit-0015","doi-asserted-by":"crossref","first-page":"H1467","DOI":"10.1152\/ajpheart.01052.2007","article-title":"11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta","volume":"294","author":"Gauthier","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0016|apha12642-cit-0016","doi-asserted-by":"crossref","first-page":"H725","DOI":"10.1152\/ajpheart.00696.2009","article-title":"Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries","volume":"300","author":"Gauthier","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0017|apha12642-cit-0017","first-page":"1","article-title":"Endothelium-derived hyperpolarizing factor-fact or fiction","volume":"15","author":"Hecker","year":"2000","journal-title":"News Physiol Sci"},{"key":"10.1111\/apha.12642-BIB0018|apha12642-cit-0018","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/01.ATV.15.7.942","article-title":"A Leukocyte type of 12-Lipoxygenase is expressed in human vascular and mononuclear cells: evidence for upregulation by angiotensin II","volume":"15","author":"Kim","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/apha.12642-BIB0019|apha12642-cit-0019","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1083\/jcb.144.4.745","article-title":"Activation of G12\/G13 results in shape change and Rho\/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets","volume":"144","author":"Klages","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/apha.12642-BIB0020|apha12642-cit-0020","doi-asserted-by":"crossref","first-page":"H2428","DOI":"10.1152\/ajpheart.01120.2011","article-title":"Mice lacking macrophage 12\/15-lipoxygenase are resistant to experimental hypertension","volume":"302","author":"Kriska","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0021|apha12642-cit-0021","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0005-2760(91)90056-N","article-title":"Hepoxilin A3 (HxA3) is formed by the rat aorta and is metabolized into HxA3-C, a glutathione conjugate","volume":"1084","author":"Laneuville","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/apha.12642-BIB0022|apha12642-cit-0022","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1139\/y01-025","article-title":"Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s)","volume":"79","author":"McGuire","year":"2001","journal-title":"Canada J Physiol. Pharmacol."},{"key":"10.1111\/apha.12642-BIB0023|apha12642-cit-0023","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1124\/jpet.102.041780","article-title":"Arachidonic acid-induced vasodilation of rat small mesenteric arteries is lipoxygenase-dependent","volume":"304","author":"Miller","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/apha.12642-BIB0024|apha12642-cit-0024","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pharmthera.2008.01.001","article-title":"Thromboxane A2: physiology\/pathophysiology, cellular signal transduction and pharmacology","volume":"118","author":"Nakahata","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1111\/apha.12642-BIB0025|apha12642-cit-0025","first-page":"113","article-title":"Increased plasma, serum and urinary 8-epi-prostaglandin F2 alpha in heterozygous hypercholesterolemia","volume":"111","author":"Oguogho","year":"1999","journal-title":"Wien Klin Wochenschr"},{"key":"10.1111\/apha.12642-BIB0026|apha12642-cit-0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0262-1746(86)90017-X","article-title":"Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid","volume":"22","author":"Pace-asciak","year":"1986","journal-title":"Prostaglandins Leukot Med"},{"key":"10.1111\/apha.12642-BIB0027|apha12642-cit-0027","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0006-291X(88)90620-1","article-title":"Formation and metabolism of hepoxilin A3 by the rat brain","volume":"151","author":"Pace-asciak","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/apha.12642-BIB0028|apha12642-cit-0028","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0262-1746(84)90069-6","article-title":"Hepoxilin, a new family of insulin secretagogues formed by intact rat pancreatic islets","volume":"16","author":"Pace-asciak","year":"1984","journal-title":"Prostaglandins Leukot Med"},{"key":"10.1111\/apha.12642-BIB0029|apha12642-cit-0029","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1016\/S0021-9258(18)32298-1","article-title":"Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids","volume":"258","author":"Pace-asciak","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1111\/apha.12642-BIB0030|apha12642-cit-0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0304-4165(03)00097-7","article-title":"Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta","volume":"1622","author":"Pfister","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/apha.12642-BIB0031|apha12642-cit-0031","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/jpet.103.056705","article-title":"The Thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPa isoform in transfected COS-7 cells","volume":"307","author":"Qiao","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/apha.12642-BIB0032|apha12642-cit-0032","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0014-5793(99)00225-2","article-title":"Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3","volume":"446","author":"Reynaud","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1111\/apha.12642-BIB0033|apha12642-cit-0033","doi-asserted-by":"crossref","first-page":"H382","DOI":"10.1152\/ajpheart.00690.2012","article-title":"Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries","volume":"304","author":"Siangjong","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1111\/apha.12642-BIB0034|apha12642-cit-0034","doi-asserted-by":"crossref","first-page":"R1110","DOI":"10.1152\/ajpregu.00410.2007","article-title":"Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia","volume":"293","author":"Stapleton","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1111\/apha.12642-BIB0035|apha12642-cit-0035","doi-asserted-by":"crossref","first-page":"53036","DOI":"10.1074\/jbc.M405002200","article-title":"Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation","volume":"279","author":"Wilson","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/apha.12642-BIB0036|apha12642-cit-0036","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1161\/hc4301.098058","article-title":"Roles of prostaglandin I2 and thromboxane A2 in cardiac ischemia-reperfusion injury","volume":"104","author":"Xiao","year":"2001","journal-title":"Circulation"},{"key":"10.1111\/apha.12642-BIB0037|apha12642-cit-0037","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0162-3109(99)00137-X","article-title":"Changes in prostacyclin, thromboxane A2 and F2-isoprostanes, and influence of eicosapentaenoic acid and antiplatelet agents in patients with hypertension and hyperlipidemia","volume":"44","author":"Yamada","year":"1999","journal-title":"Immunopharmacology"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12642","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/apha.12642\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T20:02:02Z","timestamp":1748721722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.1111\/apha.12642","archive":["Portico"],"relation":{},"ISSN":["1748-1708"],"issn-type":[{"value":"1748-1708","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}