{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:27Z","timestamp":1792787007212,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Sports","award":["07-006"],"award-info":[{"award-number":["07-006"]}]},{"name":"Region Pays de la Loire","award":["2012-13467"],"award-info":[{"award-number":["2012-13467"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Defining the origins of muscle injury has important rehabilitation and exercise applications. However, current knowledge of muscle damage mechanics in human remains unclear\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      . This study aimed to determine the relationships between muscle\u2013tendon unit mechanics during maximal eccentric contractions and the extent of subsequent functional impairments induced by muscle damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The length of the muscle\u2013tendon unit, fascicles and tendinous tissues was continuously measured on the gastrocnemius medialis using ultrasonography, in time with torque, during 10 sets of 30 maximal eccentric contractions of plantar flexors at 45\u00b0s\n                      <jats:sup>\u22121<\/jats:sup>\n                      , in seventeen participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Muscle\u2013tendon unit, fascicles and tendinous tissues were stretched up to 4.44\u00a0\u00b1\u00a00.33\u00a0cm, 2.31\u00a0\u00b1\u00a00.64\u00a0cm and 1.92\u00a0\u00b1\u00a00.61\u00a0cm respectively. Fascicle stretch length, lengthening amplitude and negative fascicle work beyond slack length were significantly correlated with the force decrease 48\u00a0h post\u2010exercise (\n                      <jats:italic>r\u00a0<\/jats:italic>\n                      =\u00a00.51, 0.47 and 0.68, respectively;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that the strain applied to human muscle fibres during eccentric contractions strongly influences the magnitude of muscle damage\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      . Achilles tendon compliance decreases the amount of strain, while architectural gear ratio may moderately contribute to attenuating muscle fascicle lengthening and hence muscle damage. Further studies are necessary to explore the impact of various types of task to fully understand the contribution of muscle\u2013tendon interactions during active lengthening to muscle damage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.12654","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T10:17:18Z","timestamp":1453285038000},"page":"152-163","source":"Crossref","is-referenced-by-count":83,"title":["Muscle force loss and soreness subsequent to maximal eccentric contractions depend on the amount of fascicle strain\n                    <i>in\u00a0vivo<\/i>"],"prefix":"10.1111","volume":"217","author":[{"given":"G.","family":"Guilhem","sequence":"first","affiliation":[{"name":"Laboratory Sport, Expertise and Performance (EA 7370) Research Department French National Institute of Sport (INSEP) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Doguet","sequence":"additional","affiliation":[{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hauraix","sequence":"additional","affiliation":[{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lacourpaille","sequence":"additional","affiliation":[{"name":"Laboratory Sport, Expertise and Performance (EA 7370) Research Department French National Institute of Sport (INSEP) Paris France"},{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jubeau","sequence":"additional","affiliation":[{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nordez","sequence":"additional","affiliation":[{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dorel","sequence":"additional","affiliation":[{"name":"Laboratory \u2018Movement, Interactions, Performance\u2019 (EA 4334) Faculty of Sport Sciences University of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.094383"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01770"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020980"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181d496eb"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.08.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.2006.10599370"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2006.08.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200211001-00007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2012.07.024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00530.2011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00309.2013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00834.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1361"},{"key":"e_1_2_7_15_1","first-page":"405","volume-title":"International Series on Biomechanics","author":"Grieve D.","year":"1978"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2010.04.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513490648"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00247.2013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2011.11.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.279166"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12159"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01431.2012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01149.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2006.05.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-005-1345-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013459"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.2800"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/33\/3\/N19"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12272"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.10.035"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.520"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.6.2498"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200210001-00011"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(90)82524-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200101000-00005"},{"key":"e_1_2_7_36_1","first-page":"42","article-title":"Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?","volume":"18","author":"Paulsen G.","year":"2012","journal-title":"Exerc Immunol Rev"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000473"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087767"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00333.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181ac7afa"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91598.2008"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2008.05.008"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:59:37Z","timestamp":1696503577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/apha.12654"],"URL":"https:\/\/doi.org\/10.1111\/apha.12654","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}